国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (3): 215-218.

• 综述 • 上一篇    下一篇

子痫前期的表观遗传学研究进展

唐 瑶, 顾蔚蓉   

  1. 200011 上海，复旦大学附属妇产科医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-06-15 发布日期:2013-06-15

Progress of Epigenetics on Preeclampsia

TANG Yao，GU Wei-rong   

  1. Obstetric and Gynecology Hospital，Fudan University，Shanghai 200011，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-06-15 Online:2013-06-15

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4940

被引次数

3

摘要： 子痫前期是一种严重的产科并发症，可导致母体多系统不可逆损伤以及胎儿生长受限。子痫前期在临床上一经诊断，终止妊娠、娩出胎盘是唯一的根治方法。国内外学者关于子痫前期发病机制有很多学说，但是具体病因至今未明。表观遗传学是相对于传统的遗传学而被研究者所认识，重点阐述DNA序列不变的情况下机体所发生的可遗传改变。最近表观遗传学在子痫前期发病中的研究方兴未艾，表观遗传的各种机制在子痫前期发生中的作用主要涉及DNA甲基化、微小RNA（miRNA）以及基因印迹三个方面。

关键词: 先兆子痫, 后成说, 遗传, DNA甲基化, 微RNAs, 基因组印迹

Abstract: Preeclampsia is a severe obstetrical complication，accompanying by maternal irreversible multiple system
damage and fetal intra-uterine growth restriction. Once diagnosed with preeclampsia，the only cure was to terminate pregnancy and deliver the placenta. Although there are many hypotheses in the mechanisms of preeclampsia，the etiology of preeclampsia is still unclear. Different from genetics，epigenetics is to elucidate inheritable changes of organism without change of genomes sequence. The role of epigenetic factors in the etiology of PE is poorly characterized. Certainly，the main analyzed epigenetics factors in preeclampsia are DNA-methylations，miRNA and gene imprinting.

Key words: Pre-eclampsia, Epigenesis, genetic, DNA methylation, MicroRNAs, Genomic imprinting