国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (3): 211-214.

• 综述 • 上一篇    下一篇

晚期糖基化终产物与子痫前期的研究进展

蒋玲玲, 颜建英   

  1. 350004 福州，福建医科大学研究生教育学院（蒋玲玲）；福建医科大学教学医院福建省妇幼保健院妇产科（颜建英）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-06-15 发布日期:2013-06-15
  • 通讯作者: 颜建英

Research Progress of Preeclampsia and Advanced Glycation End Products

JIANG Ling-ling，YAN Jian-ying   

  1. Postgraduate Institute of Fujian Medical University，Fuzhou 350004，China（JIANG Ling-ling）；Department of Obstetrics and Gynecology，Fujian Medical University Teaching Hospital，Fujian Maternity and Child Health Hospital，Fuzhou 350001，China（YAN Jian-ying）
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-06-15 Online:2013-06-15
  • Contact: YAN Jian-ying

PDF (PC)

4965

被引次数

11

摘要： 晚期糖基化终产物（advanced glycation end products，AGEs）是指蛋白质、核酸、脂质等大分子物质的氨基在无酶条件下生成的一组稳定的终末产物，既可直接损伤细胞，也能通过与受体结合发挥生物学效应。研究发现，AGEs与线粒体氧化应激损伤及脂质代谢紊乱关系密切。子痫前期是妊娠期特有的疾病，是孕产妇和围生儿患病及死亡的主要原因，但具体发病机制未明，现普遍认为线粒体氧化应激损伤及脂质代谢紊乱参与子痫前期发病。就AGEs在子痫前期发病中的作用进行综述。

关键词: 先兆子痫, 氧化性应激, DNA, 线粒体, 晚期糖基化终产物

Abstract: Advanced glycation end products（AGEs） are formed by non-enzymatic reactions between carbonyl groups of reducing sugars and free amino groups of macromolecules such as proteins， lipoproteins and nucleic acids. AGEs can directly lead to cell damage， but also can play a biological effect by binding to the receptor. Studies have shown that AGEs had a closely relationship with mitochondrial oxidative stress damage and lipid metabolism disorders. Pre-eclampsia， a hypertensive disorder which occurs only during pregnancy， is a major cause of maternal-fetal morbidity and mortality. However， the mechanisms responsible for the pathogenesis of pre-eclampsia are not completely understood. It is generally agreed that mitochondrial oxidative stress damage and lipid metabolism disorders are involved in the pathogenesis of preeclampsia. This article reviews the role of AGEs in preeclampsia.

Key words: Pre-eclampsia, Oxidative stress, DNA, mitochondrial, Advanced glycation end products