国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (1): 35-39.

• 综述 • 上一篇    下一篇

系统性红斑狼疮女性患者的生殖健康管理

张焕晓, 徐艳文   

  1. 510080 广州,中山大学附属第一医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-02-15 发布日期:2013-02-15

The Reproductive Healthcare of Women with Systemic Lupus Erythematosus

ZHANG Huan-xiao，XU Yan-wen   

  1. Department of Obstetrics and Gynecology， the First Affiliated Hospital， SUN Yat-sen University， Guangzhou 510080，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-02-15 Online:2013-02-15

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摘要： 系统性红斑狼疮（SLE）是一种好发于育龄期女性的自身免疫性疾病，雌激素暴露是其发生发展的因素之一。SLE本身及其治疗可导致卵巢功能紊乱、卵巢早衰和骨质疏松的发病率增加，而妊娠等内源性高雌激素状态或激素治疗等外源性雌激素制剂可能诱发SLE发病或者病情活动。随着治疗水平的进步，SLE妇女对妊娠、避孕和绝经后激素补充的需求逐渐增加，与其潜在的风险形成尖锐的矛盾。现从生活质量、疾病复发活动的风险、心血管事件风险、血栓栓塞风险几个角度对SLE妇女生殖健康管理的多个方面进行综述。

关键词: 红斑狼疮, 系统性, 性腺甾类激素, 避孕, 生殖技术, 辅助, 雌激素替代疗法

Abstract: Systemic lupus erythematosus（SLE） is an autoimmunologic disease that most commonly happens in women of reproductive age. Exposure to estrogen is one of the reasons that may trigger or aggravate lupus. On one hand， SLE itself as well as the treatment may cause ovarian malfunction， premature ovarian failure and osteoporosis. On the other hand， high estrogen status， such as pregnancy or hormonal supplement， may lead to relapse of SLE. As survival rate improves with the development of therapeutic measures，more and more women with SLE come to be faced with the need for pregnancy， assisted reproductive therapy or hormone replacement therapy， which brings up a potential risk of aggravating the disease. This essay aims at reviewing the reproductive healthcare of women with SLE from the aforesaid prospective.

Key words: Lupus erythematosus, systemic, Gonadal steroid hormone, Contraception, Reproductive techniques, assisted