国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (2): 128-131.

• 综述 • 上一篇    下一篇

基质金属蛋白酶在早产动因中的研究

王 芬 曹云霞   

  1. 244000 安徽省铜陵市第四人民医院妇产科(王芬);安徽医科大学第一附属医院妇产科(曹云霞)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-04-15 发布日期:2011-04-15
  • 通讯作者: 王 芬

The Research of the Matrix Metalloproteinases in the Onset of Premature Delivery

WANG Fen, CAO Yun-xia   

  1. Department of Obstetrics and Gynecology, the Fourth People Hospital of Tongling, Tongling, Anhui 244000, China （WANG Fen）; Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China （CAO Yun-xia）
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-04-15 Online:2011-04-15
  • Contact: WANG Fen

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被引次数

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摘要： 近年，无论在经济发达的国家或是边远落后地区，早产发生率均有上升趋势。早产儿死亡占新生儿死亡的45.9%～75%，存活的早产儿中8%～25%留有神经及智力方面的后遗症。早产的原因尚未阐明，但内在炎症反应是其主要病因。多种病原体可导致宫内感染，促进基质金属蛋白酶（MMPs）在成纤维细胞内快速表达，分解细胞外基质和调节氨基酸葡聚糖，刺激羊膜、蜕膜和绒毛膜产生前列腺素，从而促使胎膜早破、宫颈成熟和扩张、子宫收缩乃至胎盘剥离，导致早产的发生。

关键词: 基质金属蛋白酶类, 早产, 胎膜早破, 宫颈成熟, 绒毛膜羊膜炎

Abstract: In recent years, premature delivery has an ascending trend in whatever developed countries or poorer areas. Premature infants is 45.9%—75% of neonates mortality, while 8%—25% survived infants have nerve and intelligence sequelae. The etiology of preterm labor and deliver is still not clear. Internal inflammation reaction may be its leading pathogeny. Manifold pathogen cause infection in uterine cavity, promote matrix metalloproteinases express rapidly in fibroblasts. MMPs decompose the extracellular matrix and regulate glycosamine, thus stimulates amnion, decidua and chorion to produce prostaglandin（PG）. PG can result in the preterm premature rupture of the membranes, the cervical ripening and dilation, uterine contraction and placenta abruption. At the end, premature delivery is unavoidable.

Key words: Matrix metalloproteinases, Premature birth, Fetal membranes, premature rupture, Cervical ripening, Chorioamnionitis