国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (1): 17-20.

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OCT4在妇产科中的研究进展

张微微, 陈 勍   

  1. 510120 广州,中山大学孙逸仙纪念医院妇产科肿瘤专科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-02-15 发布日期:2013-02-15
  • 通讯作者: 陈 勍

Advances of OCT4 in Obstetrics and Gynecology

ZHANG Wei-wei， CHEN Qing   

  1. Department of Gynecology Oncology of Sun Yat-Sen Memorial Hospital，Sun Yat-Sen University，Guangzhou 510120，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-02-15 Online:2013-02-15
  • Contact: CHEN Qing

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被引次数

1

摘要： 八聚体结合因子4（OCT4）是秀丽隐杆线虫神经（POU）转录因子家族的一员，主要表达于胚胎干细胞、生殖细胞、胚胎性癌细胞和肿瘤干细胞中，被公认为是干细胞的标记物，在维持干细胞的多能性、自我更新能力及在肿瘤的恶性行为学中起着举足轻重的作用。同时OCT4也参与胚胎发育过程中多向性分化调节。近年来随着干细胞理论及其相关研究的发展，OCT4作为干细胞的标记物也被用于不同领域的研究中，综述其在妇产科领域的研究进展。

关键词: 肿瘤干细胞, 胚胎干细胞, 间质干细胞, 诊断技术, 妇产科

Abstract: Octamer-binding transcription factor 4 （OCT4） is a member of the Pit-Oct-Unc（POU） transcription factor
family，which is expressed in embryonic stem（ES） cells，germ cells，embryonal carcinoma（EC）cells，germ-cell tumors and known to play a crucial role in the maintenance of stem cell pluripotency，self-renewal and tumor malignant behavior as a marker of stem cells. Meanwhile，OCT4 also regulates the multipotent differentiation in the embryonic development. In recent years，an increasing number of persons committed to the research about stem cell theory and OCT4 in different disciplines. This paper provides an overview about OCT4 research in obstetrics and gynecology.

Key words: Neoplastic stem cells, Embryonic stem cell, Mesenchymal stem cells, Diagnostic techniques, obstetrical and gynecological