国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (5): 491-494.

• 综述 • 上一篇    下一篇

多囊卵巢综合征子宫内膜容受性研究进展

叶彩云,杨雪峰   

  1. 450052 郑州大学第三附属医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-10-15 发布日期:2012-10-15

Progress on Endometrial Receptivity of the Polycystic Ovary Syndrome

YE Cai-yun，YANG Xue-feng   

  1. Department of Obstetrics and Gynecology， the Third Affiliated Hospital of Zhengzhou University，Zhengzhou 450052，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-10-15 Online:2012-10-15

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摘要： 多囊卵巢综合征（PCOS）是育龄妇女最常见的妇科内分泌疾患。多项研究表明，子宫内膜发育不良以及内膜对胚泡植入的容受性降低，可能是导致PCOS患者生育能力低下和不良妊娠结局的原因之一，子宫内膜的分子及基因表达异常可能引起子宫内膜容受性的下降。现综述目前公认的影响子宫内膜容受性的标记物：甾体类激素及其受体、细胞黏附分子（CAMs）、基质金属蛋白酶（MMPs）和白血病抑制因子（LIF）等的研究进展。

关键词: 多囊卵巢综合征, 胚胎植入, 组织相容性, 母体胎儿, 性腺甾类激素, 细胞黏附分子, 整合素αVβ3, 基质金属蛋白酶类, 白血病抑制因子, NF-κB

Abstract: The polycystic ovary syndrome（PCOS） is one of the most common endocrinopathy of reproductive-aged women in Gynecology. There is increasing evidence showing that the disorder of endometrial development and the decrease of endometrial receptivity to blastocyst implantation may be one of causes contributing to the poor abilities of reproduction and the unsatisfied outcomes of pregnancy in PCOS patients. Aberrant expression of some molecules and genes in endometrium may contribute to diminished endometrial receptivity. The article reviewed the latest progress in the well-known characteristic markers of endometrial receptivity at present，such as，the steroid hormones of ovary and their receptors，cell adhesion molecules，matrix metalloproteinase，Leukemia inhibitory factor and so on.

Key words: Polycystic ovary syndrome, Embryo implantation, Histocompatibility, maternal-fetal, Gonadal steroid hormones, Cell adhesion molecules, Matrix metalloproteinases, Leukemia inhibitory factor, NF-kappa B