Abstract:

The trophoblasts of the hydatidiform mole and those of normal pregnancy were both originated from the ectoderm and were regulated by paternally imprinted genes. Trophoblasts of normal pregnancy during early pregnancy could induce immune tolerance at the maternal-fetal interface by expressing non-classical human leukocyte antigen and inducing immune cell suppression to ensure fetuses′ normal growth and development. However, the current understanding of the immunological changes of the hydatidiform mole was still limited. Recently, studies have revealed that the interaction between trophoblasts of the hydatidiform mole and immune cells of the maternal-fetal interface was a crucial factor that influenced the prognosis after uterine evacuation. The immune response of peripheral blood mononuclear cell (PBMC) in patients with mole was associated with the advance of mole, which reflected the adaptive changes of the patient′s immune system to the continuous pregnancy of mole. In order to explore the above-mentioned immunological characteristics of hydatidiform mole, this paper reviewed the recent research progress on the composition of immune cells at the maternal-fetal interface of hydatidiform mole and the immune status of PBMC.

Key words: Gestational trophoblastic disease, Hydatidiform mole, Immunity, Immunity,cellular, Disease progression, Peripheral blood mononuclear cell