Abstract:

Ferroptosis is a new type of programmed cell death which is iron-dependent and different from apoptosis, pyroptosis, necrosis and autophagy. It is a process of oxidative death caused by imbalance of intracellular lipid reactive oxygen species metabolism, reduction of cell antioxidant capacity and accumulation of membrane lipid peroxides. The process of ischemia-reperfusion and anoxia reoxygenation of trophoblast during the formation of maternal fetal interface can produce a lot of reactive oxygen species, and trophoblast is rich in polyunsaturated fatty acids and has a high load of iron ions, so it is a susceptible cell of iron death. Ferroptosis of trophoblast may affect its invasion and proliferation ability, resulting in insufficient placenta infiltration and poor remodeling of uterine spiral arteries, causing placental dysfunction, and is involved in the development of placental related diseases such as pre-eclampsia, preterm delivery, gestational diabetes mellitus and so on. The regulatory mechanism of trophoblast iron death is complex, which needs further study, and is expected to provide new strategies for the study and treatment of placental related diseases.

Key words: Trophoblasts, Ferroptosis, Hypertension,pregnancy-induced, Abortion,spontaneous, Diabetes,gestational