Research Progress on DNA Methylation in Predicting Cervical Cancer and Precancerous Lesions

doi:10.12280/gjfckx.20230135

Abstract

Abstract:

In recent years, with the popularization of early screening, the incidence and mortality rate of cervical cancer in China have decreased. Cytological examination and high-risk human papilloma virus(HPV) test are common screening methods for cervical cancer at present, but they both have their limitations. Cytological examination may lead to missed diagnosis, while high-risk HPV test may lead to over-diagnosis and over-treatment. Therefore, it is necessary to explore a new screening or triage method for cervical cancer. DNA methylation is a common epigenetic modality. With the development of DNA methylation detection technology, DNA methylation has played an increasingly important role in the field of oncology diagnosis and treatment. In recent years, a large amount of DNA methylation genes has been found as markers of cervical cancer, which have a promising application in cervical cancer screening and triage, and have the advantages of prognosis prediction and convenient sampling. DNA methylation is beneficial for the early diagnosis and treatment of cervical cancer. This article reviews the research progress of DNA methylation in cervical cancer and precancerous lesions.

Key words: DNA methylation, Uterine cervical neoplasms, Precancerous conditions, Early detection of cancer, Papillomaviridae

WU Ruo-Lan, QIU Li-hua. Research Progress on DNA Methylation in Predicting Cervical Cancer and Precancerous Lesions[J]. Journal of International Obstetrics and Gynecology, 2023, 50(3): 281-285.

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