Research Progress of Glucose Metabolic Reprogramming in Endometriosis

doi:10.12280/gjfckx.20230228

Abstract

Abstract:

Glucose metabolic reprogramming is an important pathophysiological alteration during tumor development. Recent studies have revealed that endometriosis (EMs) has similar reprogramming of glucose metabolism to tumor, namely the transition from mitochondrial oxidative phosphorylation to aerobic glycolysis. Glucose metabolic reprogramming, characterized by increased glucose uptake, increased lactic acid production, and decreased production of reactive oxygen species, is closely associated not only with disease progression of EMs, but also with decreased oocyte quality and impaired endometrial receptivity in patients. This review systematically reviews the research progress of glucose metabolic reprogramming in EMs, providing deeper insight into the pathophysiological mechanism of EMs.

Key words: Endometriosis, Glycolysis, Warburg effect, oncologic, Oxidative phosphorylation, Infertility, female

LIU Jun-jun, ZHANG Ling, LIU Yi. Research Progress of Glucose Metabolic Reprogramming in Endometriosis[J]. Journal of International Obstetrics and Gynecology, 2023, 50(5): 550-554.

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