Abstract:

Fetal growth restriction (FGR) is a pregnancy complication closely associated with adverse pregnancy outcomes. Early diagnosis and monitoring of FGR are crucial for improving prognosis. In recent years, studies have found that the cerebral-placental-uterine ratio (CPUR), as a novel Doppler ultrasound parameter, shows significant advantages in predicting FGR by integrating the hemodynamic indicators of the fetal middle cerebral artery, umbilical artery, and uterine artery. CPUR has high predictive potential for both early-onset and late-onset FGR. Particularly in late-onset FGR, some studies have shown that the predictive efficacy of CPUR is superior to that of traditional blood flow indicators, and it is significantly associated with adverse pregnancy outcomes such as operative delivery and perinatal mortality. In addition, the predictive value of CPUR for adverse perinatal outcomes in patients with hypertensive disorders of pregnancy and pregestational diabetes has also been preliminarily validated. This review summarizes the application value and research progress of CPUR in FGR, aiming to achieve early diagnosis and rational monitoring of high-risk fetuses with FGR though CPUR, reduce the occurrence of adverse pregnancy outcomes of FGR, and provide a theoretical basis for the clinical promotion and individualized intervention of CPUR.

Key words: Fetal growth retardation, Ultrasonography, Doppler, Pregnancy outcomes, Prenatal diagnosis, Prediction, Cerebral-placental-uterine ratio