Transient Neonatal Myasthenia Gravis of Maternal Origin: A Case Report

doi:10.12280/gjfckx.20251171

Abstract

Abstract:

Transient neonatal myasthenia gravis (TNMG) has an insidious onset, and its clinical manifestations are non-specific, making it easily misdiagnosed. It mainly occurs as a complication of maternal myasthenia gravis (MG). A case of a child with maternal TNMG is reported. The main manifestations were dyspnea, hypotonia, dysphagia, and a weak cry. The child was positive for acetylcholine receptor (AChR) antibodies. Based on the clinical manifestations and the mother's history of MG, the child was diagnosed with TNMG. After comprehensive treatment including mechanical ventilation, intravenous injection of human immunoglobulin, pyridostigmine bromide, and anti-infection therapy, the child's symptoms gradually improved. The child was cured and discharged on the 30th day after admission. During the follow-up until 6 months of age, the child's growth and development were normal. Early identification of TNMG is crucial. After individualized comprehensive intervention, the prognosis of most patients is good.

Key words: Infant, newborn, Myasthenia gravis, neonatal, Receptors, cholinergic, Diagnosis, Therapy, Prognosis

WANG Peng-yuan, YI Feng-xin, CHI Yun-qian, ZHANG Zi-han, WANG Yun-he, ZHANG Xing-ying, HAO Wei. Transient Neonatal Myasthenia Gravis of Maternal Origin: A Case Report[J]. Journal of International Obstetrics and Gynecology, 2026, 53(1): 117-120.

Figures/Tables 2

References 14

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