Abstract: Objective: To investigate the efficacy therapy for persistent ectopic pregnancy（PEP）. Methods: 155 patients with persistent ectopic pregnancy were randomly divided into 3 treatment groups: Group A received expectant treatment, Group B received methotrexate local injection treatment, and Group C received systemic administration mifepristone and methotrexate. Successful rate, failure rate, adverse reaction, treatment time and treatment cost of each groups were analyzed and compared. Results: The successful rate of Group B is highest. The failure rate of Group A is highest. The side effect in Group C is strongest, less side effect in Group B. Longer treatment time in Group A, shorter treatment time in Group C, there is no statistical differences in the time of 3 groups. The cost of Group C is highest, and Group B is lowest if the treatment is successful. Conclusions: There are a lots of treatment for persistent ectopic pregnancy, Methotrexate local injection treatment is the best therapy for persistent ectopic pregnancy.

Key words: Persistent ectopic pregnancy, Expectant treatment, Local injection treatment, Systemic administration, Methotrexate