Abstract: Nicotinamide phosphoribosyltransferase （Nampt） is a cytokine with highly conserved structure. It received little notice during the first ten years. However, since 2005, Nampt has garnered an increasing attention due to accumulating evidence indicating that Nampt is a pleiotropic protein like peptide hormone, adipocytokine and nicotinamide phosphoribosyltransferase. Nampt is not only involved in regulating of cell multiple functions, but also implicated in the pathogenesis of a number of human diseases and conditions. This review will cover the current progress of the associations among Nampt and gynecologic and obstetric diseases or conditions.

Key words: Nicotinamide phosphoribosyltransferase, Peptide hormone, Adipocytokine, Enzyme