Abstract: The human leukocyte antigen G（HLA-G） is non-classical HLA-I class I molecules highly expressing in the the extravillous trophoblast cells of maternal-fetal interface, which has protective effects to pregnancy and embryo by inducing immune tolerance. Pre-eclampsia is one of the major diseases in obstetric field, the expression of HLA-G in patients with preeclampsia, but the mechanism of action still unclear. The progress of basic research, the HLA-G gene and protein structures were defined, a lot of work have been done to clarify the relationship between HLA-G polymorphisms and preeclampsia in the gene level. It is found that some patients with pre-eclampsia maybe have HLA-G gene defect, and the distribution of HLA-G polymorphism was also different.

Key words: Human leukocyte antigen G, Preeclampsia, Gene, Polymorphism