Abstract: Gap junctions， which are specialized regions in cellular membranes， allow intercellular communication and the transfer of ions， second messengers， and small metabolites between adjacent cells. They not only mediate electrical and biochemical coupling between cells but also regulate many physiological events， including cell proliferation， differentiation and metabolism. Due to the regulation of multiple mechanism， GJs exist dynamically. During one's pregnancy， GJs timely adjust the cells proliferation and differentiation in myometrium and endometrial， then regulate uterine contraction to suit different stages of pregnancy. Thus， GJs play an essential role in the embryo implantation， placenta and embryo development， onset of labor even the regulation of parturient and pregnancy outcome.

Key words: Gap junction, Connexin 43, Regulation, Pregnancy, Parturition