Abstract: Objective：The objective is to study the expressions of P27，P73 and CyclinD1 in endometrial carcinoma and the correlation of them. Methods：14 cases of normal proliferative endometrium，19 cases of atypical hyperplasia and 43 cases of endometrial carcinoma were detected for the expression of P27，P73 and CyclinD1 by means of immunohistochemical SP. Results: In endometrial carcinoma，P27 reduced or lowexpressed，and P73 and CyclinD1 overexpressed， which were statistically significant with the expressions in normal proliferative endometrium and atypical hyperplasia group（P <0.05 or P <0.01）. Lowexpression of P27 and overexpression of P73 were related to histological grade，while overexpression of CycinD1 were ralated to FIGO stages. The abnormal expression of P27，P73 and CyclinD1 in deep invasion was significant difference with that in superficial invasion（P ＜0.05）. In the samples with lymph metastasis，P73 and CyclinD1 both overexpressed. In endometrial carcinoma，there was a opposite correlation between P27 and CyclinD1（r =-0.362 7， P <0.05）， while there was a positive correlation between P73 and CyclinD1（r =0.392 3，P <0.05）. Conclusion: So we concluded that， in endometrial carcinoma，there were lowexpression of P27 and overexpressions of P73 and CyclinD1. If detected together，the levels of P27，P73 and CyclinD1 proteins may be molecular markers for early screening of high-risk groups， and to determine the biological behavior of endometrial carcinoma and prognosis in reference.

Key words: Endometrial neoplasms, Neoplasm proteins, Cyclin D1, Gene expression regulation