Abstract: High survival rate is seen in the early stage of ovarian cancer, but survival rate is very low in advanced stage. High sensitivity and high specificity ovarian cancer markers help the early detection of ovarian cancer, no doubt will increase the survival rate of ovarian cancer. CA125 and HE4 are the most important markers for ovarian cancer and the only two by the U.S. FDA approval for clinical monitoring ovarian cancer so far. Use of tumor markers can increase ovarian cancer screening efficiency, identify malignant or benign pelvic mass, and monitoring disease status.

Key words: Ovarian neoplasms, Tumor markers, biological, Antigens, neoplasm, CA-125 antigen