Abstract: Objective：To detect the relationship between mRNA expression of three factors（TGFβ-3，Lamin，
Relaxin）with stress urinary incontienece rats model. Methods：Seperately extrat the RNA in Levator ani and Vaginal of stress urinary incontienece rats model and normal rats（8 rats）. Use the RT-PCR method to detect the continence of Levator ani and Vaginal of stress urinary incontienece rats model and normal rats. Results：Compared with SUI rats and nomal rats，TGFβ-3 mRNA expression in levator ani and vagina are significant decreased（P＜0.05）. Lamin mRNA expression in levator ani and vagina are significant decreased（P＜0.05）. Relaxin mRNA expression in levator ani and vagina are significant higher（P＜0.05）. Conclusions：There is close relationship between occurrence of SUI and deficiency of TGFβ-3 and Lamin and increasing of Relaxin.

Key words: Urinary incontinence, stress, Transforming growth factor beta 3, Lamin, Relaxin