Abstract: Large cell neuroendocrine carcinoma （LCNEC） of the cervix is a rare cervical malignancy. The prognosis of LCNEC of the cervix is very poor showing a high degree of malignity， a rapid progression， a high relapse rate and early blood spread. Its development is closely related to high-risk human papilloma virus infection. Although the cytologic abnormality can aid to the diagnosis of LCNEC of the cervix， the pathologic examination combined with immunohistochemical study is the main method for its diagnosis and differential diagnosis. There is no unified therapy at present， but a majority of scholars presume that operation combined with radiotherapy and chemotherapy can improve the survival rate.

Key words: Uterine cervical neoplasms, Carcinoma, large cell, Carcinoma, neuroendocrine, Papillomaviridae