Abstract: Objective：To analyze the clinical and pathological characteristics of patients of endometrial cancer coexisting with uterine myoma or（and） adenomyosis，and compare the high risk factors between endometrial cancer with uterine fibroids or （and） adenomyosis and pure endometrial cancer. Methods：The clinical and pathological data of 370 patients with endometrial carcinoma hospitalized to Tianjin Central Hospital of Gynecology Obstetrics from August 2010 to March 2012 were retrospectively analyzed. Patients were divided into merger uterine myoma group（group A，35.6%），merger adenomyosis group（group B，12.4%），merger uterine myoma and adenomyosis group（group C，16.1%），pure endometrial cancer group（group D，35.9%）. Results：GroupA，C are more early in clinie-pathologic staging （Zc=2.10，2.06），more superficial in myometrium invasion（Zc=1.99，2.23），more well in tissue differentiation（Zc=2.18），higher in ER，PR tested positive rate（χ2=10.83，5.78；7.75，4.13）than group D，and all differences have statitical significance（P＜0.05）. Group B is more well in tissue differentiation（Zc=2.01），higher in PR tested positive rate（χ2=3.86） than group D，and differences have statitical significance（P＜0.05）. While the other factors has no significancy compareed with group D；and there was no significant difference in groupA，B and C（P＞0.05）. The peritoneal cytology，lymph node metastasis and pathological type showed no signifiicant difference among the four groups（P＞0.05）. Conclusions：Endometrial carcinoma combined with uterine myoma mostly belongs to an estrogen-dependent tumor，with well-differentiated tissue and superficial myometrial invasion，with less high risk factors. While pure endometrial cancer mostly with more high risk factors.

Key words: Endometrial neoplasms, Uterine neoplasms, Leiomyoma, Uterine diseases, Pathology, clinical