Research Progress on Platelet-Rich Plasma Therapy in the Repair of Endometrial Injury

doi:10.12280/gjfckx.20251078

Abstract

Abstract:

Endometrial injury induced diseases such as thin endometrium, chronic endometritis, and intrauterine adhesions are the main diseases affecting female reproductive health, and their clinical treatment still faces bottlenecks. Platelet-rich plasma (PRP) therapy, as a regenerative medicine approach, shows broad prospects in the repair of endometrial injury and functional reconstruction by releasing various growth factors and cytokines. Studies have demonstrated that PRP can promote the proliferation of endometrial-derived mesenchymal stem cells, stimulate angiogenesis, inhibit the inflammatory response and fibrotic process, and regulate cell apoptosis, thereby increasing endometrial thickness, improving the immune microenvironment, reducing the risk of adhesion recurrence, and enhancing the pregnancy rate. However, the clinical application of PRP still faces many problems that need to be solved urgently, including the lack of unified standards for its preparation, the unclear individualized clinical application protocols, and the relatively limited research on its non-growth factor components. This review summarizes the preparation, mechanism of action and research progress of PRP in the repair of endometrial injury, aiming to provide new ideas and strategies for clinical treatment.

Key words: Platelet-rich plasma, Endometrium, Uterine diseases, Endometritis, Tissue adhesions, Thin endometrium

YU Mao, LIN Zhong, ZHU Xue-hong, MO Si-en. Research Progress on Platelet-Rich Plasma Therapy in the Repair of Endometrial Injury[J]. Journal of International Obstetrics and Gynecology, 2026, 53(1): 65-72.

Figures/Tables 3

References 39

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疾病	主要病因机制	主要病理特点	诊断标准	常用治疗方式
TE^[6]	器械/药物直接损伤	EEC、EnMSC及腺体数量骤降；VEGF降低；子宫动脉血流阻力增加	子宫内膜厚度<7 mm	雌激素为主的激素类药物
CE^[7]	微生物感染	浆细胞在子宫内膜间质区持续浸润	≥1个浆细胞/高倍视野	广谱抗生素
IUA^[8]	内膜过度纤维化	成纤维细胞过度增殖；ECM过度沉积	宫腔镜评估粘连程度	宫腔镜下宫腔粘连分离术

疾病	主要病因机制	主要病理特点	诊断标准	常用治疗方式
TE^[6]	器械/药物直接损伤	EEC、EnMSC及腺体数量骤降；VEGF降低；子宫动脉血流阻力增加	子宫内膜厚度<7 mm	雌激素为主的激素类药物
CE^[7]	微生物感染	浆细胞在子宫内膜间质区持续浸润	≥1个浆细胞/高倍视野	广谱抗生素
IUA^[8]	内膜过度纤维化	成纤维细胞过度增殖；ECM过度沉积	宫腔镜评估粘连程度	宫腔镜下宫腔粘连分离术