Application of Organoids in Research of Endometrium and Endometrium-Related Diseases

doi:10.12280/gjfckx.20230197

Abstract

Abstract:

Organoids are three-dimensional cellular models cultured in vitro that retain the histological, physiological, and genetic characteristics of original tissues in vivo. They have the advantages of short culture time and high proliferative efficiency. In recent years, organoids have been widely applied in the field of life sciences, particularly in the endometrial research. By overcoming the limitations of conventional cell and animal models, organoids provide a more accurate simulation of the cyclic physiological changes of the endometrium and the characteristics of embryo implantation. Additionally, they show significant potential in disease modeling, precision medicine, drug screening for endometrium-related diseases such as endometriosis, endometrial tumors, and infertility. This review summarizes the progress in the application of organoids in translational research of basic endometrial and related diseases.

Key words: Organoids, Endometrium, Endometriosis, Endometrial neoplasms, Infertility, female

ZHANG Xiao-lei, DENG Dan-ni, GAO Yan, ZHANG Hui-min. Application of Organoids in Research of Endometrium and Endometrium-Related Diseases[J]. Journal of International Obstetrics and Gynecology, 2023, 50(4): 446-449.

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