Abstract: The mechanisms responsible for the pathogenesis of preeclampsia are poorly understood by now，which is important reason for maternal-fetal death. P-selectin is one of adhesion molecules，having a start and an enlarged role of inflammation and thrombus formation，resulting in coagulation dysfunction，damage to the capillary endothelial cells，thereby causing specific maternal-fetal clinical manifestations，which mainly comes from platelets. Many studies have confirmed that P-selectin play an important role in the pathogenesis of preeclampsia. In the article，we will make a review about this progress.

Key words: P-selectin, Pre-eclampsia, Pregnancy, Therapy