Abstract: Objective：To investigate the clinical efficacy of the heparin and low-dose aspirin in the treatment of unexplained recurrent spontaneous abortion. Methods：In 78 patients with unexplained recurrent spontaneous abortion，patients were randomly divided into observation group（39 cases） and control group（39 cases）. The observation group treated with heparin and aspirin therapy. The control group treated with progesterone，chorionic gonadotropin therapy. To compare the outcome of pregnancy，adverse drug reactions，blood coagulation index，and pregnancy complications of the two groups. Results：The therapeutic efficacy was statistically significant between observation group and control group（P＜0.05）. Drug side effects and pregnancy complications of the two groups had no statistical significance（P＞0.05）. Conclusions：Heparin combined with low-dose aspirin in the treatment of unexplained recurrent spontaneous abortion can improve the success rate of pregnancy. This method is safe and effective and is worthy of clinical promotion.

Key words: Abortion, habitual, Heparin, Aspirin, Therapy