Abstract: MicroRNA-375 is a highly conservative miRNA，which play important roles in suppressing proliferation，promoting apoptosis，suppressing invasion and metastasis by means of regulating the expression of genes. The research has revealed that miR-375 is remarkably down-regulated in many tumor cells and ontic tissues，and is closely related in cancer development and progression. Recent years，the research on miR-375 in cervical cancer and endometrial cancer is increasing，but the mechanism should be studied future. This article elaborates biological function of miR-375 and improvements of some studies in gynecological malignant tumors.

Key words: MicroRNAs, Neoplasms, Uterine cervical neoplasms, Endometrial neoplasms, Cell proliferation, Apoptosis