Abstract: Objective：To build the rat model of endometriosis by reflux method, observed the preventive effect of reversible oviduct synthetic on endometriosis in rats. Methods：The rats were divided into three groups randomly, experimental group（molding by reflux method and placement reversible oviduct synthetic）, negative control group（molding by reflux method）, blank control group（no processing）. Then tested EmAb and CA125 in serum, and observed the tissue morphological variations in eight weeks after operation. Results：There were difference in EmAb and CA125 in serum between three group (P＜0.05), and the negative control group was significantly higher than the experimental group and blank control group (P＜0.05). There were also no obvious difference in histomorphology between the experimental group and the blank group. Neither of them developed endometriosis. In histomorphology observation, there is none in blank control group, 8 cases in negative control group, ectopic lesions volume（74.20±6.30）mm3, 1 case in experimental group, volume for the onset of ectopic lesions 1.50 mm3. Conclusions：The reversible oviduct synthetic could prevent endometriosis in rats.

Key words: Endometriosis, Contraceptive devices, Fallopian tubes, Animal experimentation, Rats, Wistar