Journal of International Obstetrics and Gynecology ›› 2015, Vol. 42 ›› Issue (3): 245-248.

• 综述 •     Next Articles

Inflammasome Antiviral Signaling Pathway and Cervical Cancer

LUO Yuan-cai,ZHANG Yu-hua   

  1. Department of Obstetrics and Gynecology,Tianjin First Central Hospital,Tianjin 300192,China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-06-15 Online:2015-06-15
  • Contact: ZHANG Yu-hua

Abstract: The inflammasome is large molecule and multiprotein complex existing in immune active cells,which can feel external pathogens such as bacteria and viruses to activate cysteinyl aspartatespecific protease 1(caspase-1),and promote the precursors of interleukin 1 β(IL-1β) and IL-18 to process and mature,involve in the body′s inflammatory response and immune response,induce a special type of cell death called pyroptosis. Pyroptosis is a kind of programmed cell death which is different from apoptosis and necrosis,its characteristics is that osmotic collapse occurs during the process of cells death and releases large amounts of inflammatory cytokines,produces proinflammatory effects on adjacent cells,starts innate immune quickly and fights against tumor formation. The inflammasome antiviral signaling pathway research progress associated with cervical cancer in recent years are reviewed.

Key words: Multiprotein complexes, Uterine cervical neoplasms, Papillomaviridae, Caspase 1, Interleukin-1beta, Pyroptosis