Journal of International Obstetrics and Gynecology

Journal of International Obstetrics and Gynecology ›› 2016, Vol. 43 ›› Issue (6): 669-672.

• 综述 • Previous Articles     Next Articles

Research Progress of S100A8 and S100A9 Proteins in Ovarian Neoplasms

WU Cai-liang, YANG Yong-xiu   

  1. The First Medicine School of Lanzhou University, Lanzhou 730000, China(WU Cai-liang); Department of Obstetrics and Gynecology ,The First Hospital of Lanzhou University, Lanzhou 730000, China(YANG Yong-xiu)
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-12-15 Online:2016-12-15
  • Contact: YANG Yong-xiu

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Abstract: S100 proteins are small calcium binding proteins, which encoded by genes located in the epidermal differentiation complex, and they are expressed exclusively in vertebrates and are indispensable for normal epidermal differentiation. S100A8 and S100A9 proteins belong to S100 proteins family, which act as homodimers and heterodimers in regulating many cellular functions. S100A8 and S100A9 were associated with inflammatory by inducing the expression of cytokines, such as IL-1β, TNF-α, IL-17, IL-6. Meanwhile, many researchers discovered both of them are connected with development of tumors by acting with Wnt signaling pathway, RAGE and Akt1/Smad5-ID 3-p21 signaling to impact on proliferation, apoptosis and invasiveness. Besides, S100A8 and S100A9 act as regulator of tumor drug resistance by activating ERK1/2 and p70S6K. Herein, we review the progress of S100A8 and S100A9 proteins in ovarian neoplasms.