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    述评
    The Past,Present and Future of Cervical Cerclage
    LI Tin-chiu;XIAO Yu
    2016, 43 (6):  605-608. 
    Abstract ( 1218 )   PDF (528KB) ( 6004 )  
    Cervical incompetence, an important cause of mid-trimester loss or preterm birth, is characterized by painless cervical dilation in the absence of uterine contractions or bleeding. Cervical cerclage has been used for many years to treat cervical incompetence. This review will focus on a number of practical issues relating to cervical cerclage, namely, diagnosis,indications,contraindications for cervical cerclage, choosing the surgical approach(vaginal, laparoscopy and laparotomy), deciding when to do it (before or during pregnancy), finding out if the suture has been correctly placed, and considering when to use medical adjuvant therapy such as progesterone and antibiotics and when to removal of cervical suture. Laparoscopic cervical cerclage is becoming increasingly popular especially as a recent report suggested that it is no longer necessary to dissect the bladder away from the lower segment of the uterus in order to insert the cervical cerclage(simplified laparoscopic cervical suture). It means that learning how to perform the procedure is easier, with a shorter learning curve. The finding has far reaching implications and will undoubtedly change clinical practice in the near future.
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    专家论坛
    Transabdominal Cerclage-the Liverpool Experience
    Farquharson RG;LI Yun-fei
    2016, 43 (6):  609-613. 
    Abstract ( 1846 )   PDF (572KB) ( 6030 )  
    After mid- trimester loss(MTL) between 12 and 24 weeks gestation, cervical incompetence is found to be common cause. In a subsequent pregnancy when transvaginal cerclage has failed, the recent recommendation is to consider transabdominal cerclage(TAC) insertion with 90% success rate. This chapter highlights the experience of over 20 years use of TAC in a single centre. Preconceptual TAC insertion is compared to first trimester use while the presence of other pathology increases the preterm delivery rate. In summary, preconceptual TAC(PC TAC) is more successful in preventing repeat spontaneous mid-trimester loss and preterm labour and is associated with less surgical and pregnancy-related morbidity compared to first trimester TAC insertion(T1 TAC). Women with MTL represent a heterogeneous group, with widely varying presentations and aetiology. The true incidence of this pregnancy complication is difficult to ascertain as no accurate data collection has been published. In Liverpool UK, a standardised protocol with baseline prepregnancy investigations has been universally employed since the late 1980′s. Causative factors include anti-phospholipid syndrome, cervical incompetence, infection and congenital uterine anomaly. Following screening of 504 consecutive cases of MTL, we have found one potential cause in 50%, dual causes in 10% and triple causes in 1%.
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    Clinical Application of the Modified Transvaginal Cervicoisthmic Cerclage
    ZHANG Song-ying;WEI Min-ling;JIN Xiao-ying
    2016, 43 (6):  614-617. 
    Abstract ( 1219 )   PDF (479KB) ( 5987 )  
    Cervical incompetence is an important factor of the late inevitable abortion and preterm birth, and the cervical cerclage has been used for many years to treat cervical incompetence. The modified transvaginal cervicoisthmic cerclage is a promising and safe technique for improving obstetric outcomes in women with cervical insufficiency, and avoid the requirement of repeated transabdominal operation. The operation indication, technique, opportunity and complication were described in this paper.
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    Complications of Cervical Cerclage
    XIA En-lan
    2016, 43 (6):  618-622. 
    Abstract ( 1783 )   PDF (543KB) ( 6383 )  
    Cervical cerclage is the only effective treatment for cervical incompetence. Its incidence of complications is low and less reported. Its severe complication is very rare. The most common complications include premature rupture of membranes, chorioamnionitis, endometritis, perioperative bleeding, cervical laceration, cerclage suture or cerclage tape shift, etc. Rare complications is fistula between cervical and bladder or ureter. The complications of transvaginal cervical cerclage are higher than transabdominal cervical cerclage. The incidence of complications is difference due to the timing of cervical cerclage and its indications. Complications are always increasing along with the increase of gestational age and the expansion of the cervix. The risk of complications can increase when the membranes ruptured or cervical dilated. So must be master the indications and contraindications strictly, as well as choose the suitable operation time to perform cervical cerclage. It have proved that the puncture point and position of cerclage tape influence on the pregnant outcome directly. When the cervical cerclage tape is near the cervical inner, the pregnant outcome is better. In general activity restriction and bed rest is needed after cervical cerclage. Progesterone and prophylactic tocolytics is used that if the uterus is higher sensitivity. Antibiotics should be used when a history or signs of infection exist. Screening and treatment of vaginal infections, close monitoring the conditions of mother and fetus, paying attention to the possible complications of cervical cerclage is helpful to increase the successful rate of surgery. After laparotomic or laparoscopic cerclage the delivery mode is cesarean section. If there are signs of labour, cesarean section should be done immediately to avoid cervical laceration or uterine rupture.
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    Pessary Placement in the Prevention of Spontaneous Preterm Birth and Its Follow-up
    QU Xiao-xian;BAO Yi-rong;HAN Huan;YING Hao
    2016, 43 (6):  623-625. 
    Abstract ( 1980 )   PDF (467KB) ( 5942 )  
    Prevention of spontaneous preterm birth is an important public health priority. Pessary may be a potential therapy in cases of cervical insufficiency in singleton and multiple gestations. As a promise alternative treatment for women with cervical insufficiency, cervical pessary is an attractive option given that it is noninvasive, easy to use, low cost, not requiring anesthesia and can be easily placed and removed. At present, many studies have shown conflicting results. In our hospital, we followed up these patients for the complaints, vaginal discharge and cervical length after placing cervical pessary for cervical insufficiency. The aim was to evaluate the effectiveness of adjunctive pessary therapy after cervical cerclage in improving perinatal outcome in women with cervical insufficiency. In the meantime, further large multicenter, randomized, controlled prospective studies are warranted to define the contribution of each treatment option for short cervix and how they may be combined for maximum effect.
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    The Application Value of Emergency Cervical Cerclage
    HUA Yan-jiao;SUN Yan;QIN Li-yuan;JIANG Xiao-li;LI Hong-hua
    2016, 43 (6):  626-629. 
    Abstract ( 1129 )   PDF (511KB) ( 5979 )  
    Cervical insufficiency is one of the leading causes of middle-late stage abortion and premature birth. Cervical cerclage may be the main operation method to treat and the effect has been the hot topic for the scholars both at home and abroad. Emergency cervical cerclage is in order to prolong the immature fetal gestational age under the emergency circumstances. But it remains controversial in single or multiple pregnancy, choosing of operation type, the delivery method , the treating of complications , the management of peri-operative and pregnancy outcome. We want to discuss the application value of the emergency cerclage and provide the treatment basis for the clinical in this paper.
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    综述
    The Aetiology and Diagnosis of Cervical Incompetence
    WANG Yong-qing;ZHAO Yang-yu
    2016, 43 (6):  630-633. 
    Abstract ( 1144 )   PDF (558KB) ( 5978 )  
    As an important role for "preterm birth syndrome", cervical incompetence cause a big impact to late miscarriage/preterm birth. Its aetiology remain unclear. By now, there is no diagnostic test for cervical incopetence, nor is there a universally accepted definition. The research of its aetiology contains congenital aetiology, such as deformity, race and genetic heritage, etc; acquired aetiology, such as surgery or birth trauma and other causes, such as inflammation, oxidative stress state, etc. The diagnosis of cervical insufficiency mainly from the history and clinical manifestation, diagnostic test and ultrasonic doppler. This review mainly discusses the aetiology and diagnostic criteria of cervical insufficiency, analysing the present research situation, and putting forward the new thoughts and suggestions.
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    论著
    Clinical Application of Simplified Laparoscopic Cervical Cerclage
    ZHAO Yu-ting;HUANG Xiao-wu;XIA En-lan;MA Ning;GUO Yan
    2016, 43 (6):  634-637. 
    Abstract ( 1280 )   PDF (569KB) ( 5994 )  
    Objective: To investigate the efficacy of simplified laparoscopic cervical cerclage (SLCC) in the prevention of miscarriage and preterm delivery in women with cervical incompetence, who failed to have a baby by vaginal cervical cerclage in previous pregnancy. Methods:Evaluate the clinical data of 153 patients who underwent SLCC for cervical incompetence in Fuxing Hospital from December 2010 to August 2015. The mean number of second trimester pregnancy loss was (2.7±1.2). The mean gestational age of previous second trimester miscarriage was (20.0±3.5) weeks. Results:Among the 153 cases of SLCC, all the patients received a successful operation and no serious complications occurred, the mean surgical time was (33.0±1.3) min, the mean volume of blood loss was (9.7±8.3) mL. 117 women conceived after the surgery, 8 of them conceived twice. There were 125 pregnancies, including 20 early miscarriages and twice ectopic pregnancies and one case of molar pregnancy. There were 19 ongoing pregnancies, and 83 confirmed the final outcome, the live birth rate was 96.4%(80/83). The mean gestational age at delivery was (37.2±2.2) weeks. Conclusions:The SLCC is a simple, safe, and effective treatment for cervical incompetence who had a failed vaginal cervical cerclage.
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    Laparoscopic Cervical Cerclage during Pregnancy by Using an Elevate-cup at First Trimester: 20 Cases Analysis
    MA Ning;XIA En-lan;HUANG Xiao-wu;LI Tin-Chiu
    2016, 43 (6):  638-642. 
    Abstract ( 1273 )   PDF (626KB) ( 5893 )  
    Objective: Report a simplified procedure by using an elevate-cup in Laparoscopy for Transabdominal Cervical Cerclage (LTCC) during pregnancy and follow-up the obstetrical outcomes. Methods: Retrospective study was carried out in Fuxing Hosptial, Captial Medical University, hysteroscopic center. From July 2013 to January 2016, 20 cases pregnancy women with cervical incompetence underwent LTCC by using an elevate-cup at first trimester. We described the surgical techniques along with the obstetrical outcomes including the success and complication rate. Results: Among the 20 cases of LTCC, the surgical time was (59.2±21.7) min (24-110 min) and blood loss was 10(10,15) mL(5-100 mL). 1 case was converted to laparotomy because of poor operation field. Postopertative morbidity rate was 0%. There were 2 cases of miscarriage after the operation. 18 women had delivered 19 live babies by cesarean section in the third trimester,live birth rate was 90%(18/20). 1 of them conceived twins. The mean gestational age at delivery was(37.5±1.3) weeks. Neonatal weight was (3 348.8±407.4) g. Conclusions: The present study reports a series of cervical incompetence cases treated by LTCC using an elevate-cup simplified surgical procedure which is easy-operating, minimal invasive and highly effective. The obstetrical outcomes are acceptable.
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    Evaluation of Different Indications for Pregnancy by Transvaginal Cervical Cerclage Results
    ZHANG Shan-shan;CHEN Yue
    2016, 43 (6):  643-646. 
    Abstract ( 1119 )   PDF (594KB) ( 5915 )  
    Objective:To retrospectively analyze the pregnancy outcome and neonatal prognosis of transvaginal cervical cerclage during pregnancy based on three different indications. Methods:Records of 66 patients with transvaginal cervical cerclage were retrospectively analyzed. Results:There were no statistically significant differences between elective cerclage group and ultrasound-indicated cerclage group in gestational age, live-birth rate and neonatal birth weight(P>0.05). The gestational age was(29.17±6.44) weeks in the emergency cerclage cervical group was lower than(34.06±6.66) weeks in the elective cerclage group and(35.42±4.75) weeks in the ultrasound-indicated cerclage group,the difference was statistically significant(P<0.05). In the emergency cerclage cervical group,the mean cervical dilation before operation,postoperative white blood cell count,highest level of C-reactive protein of the failure group were higher than the successful group. Conclusions:Pregnancy women with elective cervical cerclage and pregnancy women with ultrasound-indicated cerclage all achieve good and similar pregnancy outcome. Through effective strengthen anti-inflammatory, emergency cerclage cervical success rate can be improved. Caesarean re-pregnancy women those who have a certain probability of occurrence of cervical incompetence during pregnancy should check changes in the cervix by B-ultrasound.
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    Perioperative Care of Laparoscopic Cervical Cerclage
    GAO Xiao-wei;YANG Wen-hui
    2016, 43 (6):  647-649. 
    Abstract ( 1142 )   PDF (619KB) ( 5919 )  
    Objective: To discuss the perioperative care of laparoscopic cervical cerclage for earlier pregnancy and preconception women. Methods:From July 2013 to December 2015 there were 331 cases who suffered from cervical incompetence and infertility admitted in Hysteroscopic Center of Fuxing Hospital. Among them 20 cases were ongoing early pregnancy. Laparoscopic cervical cerclage was performed. Perioperative care of laparoscopic cervical cerclage for pregnant and preconception women include psychological counseling, perfect preoperative preparation and transition between ward and operating theatre, postoperative close observation of patient′s conditions, medication care and active guidance, education of health and notes while discharge. Results:There were 311 cases preconception laparoscopic cervical cerclage, 216 cases with pregnancy successful after operation,cesarean sections were performed for 187 cases during 29-39 gestation weeks,191 live babies(4 twins). Among them 35 cases with premature delivery, 21 cases with ongoing pregnancy, 8 cases with midtrimester abortion. Laparoscopic cervical cerclage was performed during pregnancy in 20 cases. Among them 18 cases with successful delivery, one twins and two other cases with unfortunate abortion. Conclusions:Laparoscopic cervical cerclage can prevent miscarriage or premature birth caused by cervical incompetence effectively. Enhanced the perioperative care is helpful to achieve good surgical outcomes.
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    标准与指南
    The Interpretation of ACOG Cerclage for the Management of Cervical Insufficiency
    XIA En-lan
    2016, 43 (6):  652-656. 
    Abstract ( 1454 )   PDF (671KB) ( 6353 )  
    Cervical incompetence (cervical insufficiency, incompetent cervix) is a clinical diagnosis disease. However, the diagnosis is very fuzzy, lack of objective gold standard. In the medical literature on cervical incompetence its pathological physiology, screening method, diagnosis and treatment is controversial. The United States in February 2014, The American College of Obstetricians and Gynecologists(ACOG) has issued guidelines of the cervical cerclage treatment for cervical incompetence, which is much strong clinical practicability. In this paper, the literature basis and the level of evidence was shown by systematic review and summary about the definition of the cervical incompetence, etiology, diagnosis, treatment options among nonsurgical and surgical modalities, the candidates should not be considered for cervical cerclage morbidity of cervical cerclage, the role of postoperative ultrasonographic assessment for additional perioperative interventions, time of remove sewing material for transvaginal McDonald cerclage indicated in patients with no complications, the time of remove out sewing silk of women with cerclage and preterm premature rupture of membranes should be managed. Should cerclage be removed in women with preterm labor etc. Points out that at present there is no guideline for the treatment of cervical incompetence in China, in general more emphasis on bed rest and cervical cerclage operation. Compared with obstetrician and gynecologist in China,European and American doctors is more careful for cervical cerclage surgery.
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    讲座
    Cervical Structure and Cervical Function
    HUANG Xiao-wu;XIA En-lan
    2016, 43 (6):  657-660. 
    Abstract ( 1290 )   PDF (704KB) ( 6059 )  
    The cervix is a barrier between the uterus and vagina,it is the organizational structure with dynamic change, the structure of cervix has a progressive change during pregnancy, including softening, shortening, funneling, effacing, dilating and postpartum repair, which is called "cervical remodeling". Any congenital malformation or injury of cervix will cause cervical incompetence,result in premature birth or abortion. A series of physiological and pathological changes of cervix before pregnancy, during pregnancy are described in this paper.
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    The Management of the Pregnant Women after Insertion of Cervical Cerclage
    YU Jin-jin
    2016, 43 (6):  661-663. 
    Abstract ( 1250 )   PDF (651KB) ( 5918 )  
    Cervical cerclage has been widely used to prevent preterm labor in patients with cervical incompetence. It is worthy for clinicians concerning and discussing some issues such as the use of antibiotics and contraction inhibitors during perioperative period , also the time and method of termination of pregnancy, and the management of retained suture lines. This article will focus on important issues about the management of the pregnant women after insertion of cervical cerclage by reviewing some domestic and overseas literatures and Affiliated Hospital of Jiangnan University clinical experiences.
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    综述
    Research Progress of Nrf2/ARE Pathway and It′s Role in Ovary
    CHEN Jing;LU Xiao-sheng;LYU Jie-qiang
    2016, 43 (6):  665-668. 
    Abstract ( 1280 )   PDF (680KB) ( 5974 )  
    Nuclear factor erythroid-derived factor 2-related factor 2(Nrf2) is a key factor in anti-oxidation in most species. Once oxidative stress stimulus occurs, Nrf2 transfers into the nucleus, and binds to antioxidant response element (ARE), and then regulates the expression of a variety of antioxdants and detoxifying enzymes to protect cells against oxidants injury. The Nrf2/ARE pathway involvs in the pathological process of many diseases, such as inflammation, respiratory disease, cardiovascular disease and tumor. But there is not enough research about its function in the female reproductive system, especially in ovary. In this article, we reviews the basic components of Nrf2/ARE pathway and its regulation, and the advanced study of this pathway in ovarian diseases, especially in ovarian aging.
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    Research Progress of S100A8 and S100A9 Proteins in Ovarian Neoplasms
    WU Cai-liang;YANG Yong-xiu
    2016, 43 (6):  669-672. 
    Abstract ( 1253 )   PDF (700KB) ( 5892 )  
    S100 proteins are small calcium binding proteins, which encoded by genes located in the epidermal differentiation complex, and they are expressed exclusively in vertebrates and are indispensable for normal epidermal differentiation. S100A8 and S100A9 proteins belong to S100 proteins family, which act as homodimers and heterodimers in regulating many cellular functions. S100A8 and S100A9 were associated with inflammatory by inducing the expression of cytokines, such as IL-1β, TNF-α, IL-17, IL-6. Meanwhile, many researchers discovered both of them are connected with development of tumors by acting with Wnt signaling pathway, RAGE and Akt1/Smad5-ID 3-p21 signaling to impact on proliferation, apoptosis and invasiveness. Besides, S100A8 and S100A9 act as regulator of tumor drug resistance by activating ERK1/2 and p70S6K. Herein, we review the progress of S100A8 and S100A9 proteins in ovarian neoplasms.
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    Mechanisms of Lysophosphatidic Acid Involved in the Progression of Ovarian Cancer
    ZHENG Ya;SUN Hong
    2016, 43 (6):  673-676. 
    Abstract ( 1215 )   PDF (795KB) ( 5826 )  
    In the development of ovarian cancer, the aberrant lipid metabolism plays a critical role. Lysophosphatidic acid (LPA), a bioactive molecular, can bind to different G protein-coupled receptors and stimulate the proliferation, metastasis and invasion of ovarian cancer. On one hand, LPA could stimulate proliferation by promoting angiogenesis, regulating cell cycle, inhibiting apoptosis, promoting glucose metabolism and maintaining cancer stem cell (CSC) characteristics. On the other hand, LPA could stimulate the metastasis and invasion by enhancing the expression of matrix metalloproteinases (MMPs) and urokinase-type plasminogen activator (uPA), interfering intercellular junctions and cytoskeletons and inducing epithelial-mesenchymal transition (EMT). Besides, testing plasma level of LPA alone or combining with other tumor biomarkers is more sensitive and specific. In this article, we review the latest knowledge on the molecular mechanism of LPA in the proliferation, migration and invasion of ovarian cancer as well as potential biological targets.
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    Fertility-sparing Surgery in Borderline Ovarian Tumor
    WANG Yi-chen;ZHU Tao
    2016, 43 (6):  677-680. 
    Abstract ( 1222 )   PDF (705KB) ( 5967 )  
    Borderline ovarian tumor(BOT) is characterized by histopathologic features and biologic behaviors, which intermediate between clearly benign and frankly malignant ovarian tumors. Most patients are young and in need of fertility. The majority of BOT are diagnosed at early stage, with good prognosis. Factors that are detrimental to survival are stage of the disease, the occurrence of invasive peritoneal implants and residual tumor. Fertility-sparing surgery is safe for early stage patients with no influence in overall survival. Fertility preservation is not found to be associated with an increased risk of relapse in young patients with advanced disease, and may be reasonably considered and performed on the base of comprehensive staging surgery. Laparoscopic conservative surgery has meaningful influence on recurrence rate, but has no influence on survival rate. Laparoscopic conservative surgery can be accepted under close follow-ups.
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    Advances in the Etiology of Endometriosis-associated Ovarian Cancer
    YIN Qi;SHENG Xiu-jie
    2016, 43 (6):  681-685. 
    Abstract ( 1290 )   PDF (767KB) ( 5946 )  
    Endometriosis (EMs) is a benign lesions on pathology, but it has similar characteristics with malignant tumor such as infiltration, plant growth and damage the surrounding tissue, distant metastasis, and easy to relapse. Moreover, having a certain proportion of EMs histomorphology changes will happen, from atypical endometrial ectopic tissues further into cancer. Recently, EMs malignant transformation has received extensive attention of scholars from all over the world. Although the connection between EMs and ovarian cancer has been reported by scholars and has accepted diagnostic criteria, with the increase of the incidence of endometriosis and ovarian cancer, etiology, mechanisms and the epidemiological characteristics of endometriosis-associated ovarian cancer(EAOC) have become a research focus in recent years. This artical is to review the current data regarding the pathogenesis of EMs malignant transformation associated with gene mutation, apoptosis, inflammation, immunity, oxidative stress, estrogen.
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    Advances of the Study for Clear Cell Adenocarcinoma of the Cervix
    GUO Jia-qi;YAO Liang-qing;YUAN Lei
    2016, 43 (6):  686-689. 
    Abstract ( 1706 )   PDF (739KB) ( 6107 )  
    Clear cell adenocarcinoma of the cervix(CCAC), tending to occur in young women,is a rare uterine cervical neoplasms. Different from common cervix cancer, CCAC may not relate with high-risk HPV infection. It has a strong association not only with a history of exposure to diethylstilbestrol (DES) in utero but also other factors, and is characterized by slower growing while early metastasis, deep infiltration and poor prognosis. Patients with CCAC commonly present with an abnormal vaginal bleeding or discharging. According to the lower frequency of abnormal cervical cytology, it is difficult to diagnose CCAC in early stage. Diagnosis is based on histologic confirmation with immunohistochemical information. Up to now there has not been a standard treatment for CCAC, most patients are treated surgically for early stage, while chemoradiation with platinum-based chemotherapy for late stage. Operation combined with radiotherapy and chemotherapy can improve the prognosis of patients with early stage. It′s feasible to have fertility-preserving treatment for specific patients. To improve the clinical management, we review its clinical characteristics and advances in both diagnosis and treatment.
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    论著
    Effect of Adhesion Molecular CD146 on Apoptosis of Ovarian Cancer Cell Induced by Vorinostat
    MA Xiao-li;LIU Yu-sheng;YAN Xi-yun;GUO Yin-shu;DUAN Hua;MA Ding
    2016, 43 (6):  690-694. 
    Abstract ( 1731 )   PDF (841KB) ( 8842 )  
    Objective:To investigate the effect of adhesion molecular CD146 expression on apoptosis of ovarian cancer cells induced by Vorinostat. Methods:CD146 expression levels in A2780 and SKOV3 cells were detected after Vorinostat treatment by Real-time PCR and Western blot. The effect of CD146 mAb AA98 on cell apoptosis and colony-forming ability under Vorinostat treatment by FACS and Soft agar colony-forming assay. The synergistic effect of Vorinostat and AA98 was analyzed by gold formula method. Comparison of effect on AKT/mTOR signaling pathway and the downstream molecular between ovarian cancer cells treated by Vorinostat alone or plus with AA98. Results: CD146 was significantly induced by Vorinostat in ovarian cancer cells. Upregulation of CD146 is closely related to chemosensitivity. Combined Vorinostat and AA98 significantly improved cell apoptotic rate and ablated cancer colony formation. The difference was statistically significant (P<0.05). The synergistic effect after treatment with a combination of Vorinostat with AA98 was proved by gold formula method. AA98 could reduce the activation of AKT/mTOR signaling pathway caused by Vorinostat and could decrease the p-AKT,p-4E-BP1,p-S6K1 protein levels in ovarian cancer cells (P<0.05). Conclusions: Vorinostat significantly induced the expression of CD146, which might decrease the chemosensitivity of ovarian cancer cells. CD146 mAb may reverse and inhibit the activation of AKT/mTOR signaling pathway caused by Vorinostat and substantially enhance killing of ovarian cancer cells. The two drugs have obvious synergistic antitumor effects.
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    综述
    Progress of Proteomics Applied to the Early Pregnancy Abortion
    YAO Ting;HOU Hai-yan;CHEN Juan;CHEN Ya-qiong
    2016, 43 (6):  699-702. 
    Abstract ( 1054 )   PDF (789KB) ( 5870 )  
    Pregnancy is similar to semi allograft transplantation,the imbalance of the maternal-fetal interface coordination is closely related to early pregnancy abortion,such as:early spontaneous abortion, recurrent spontaneous abortion, but the pathogenesises are unclear. Proteomics is a scientific discipline which can analysis the composition,function and the relationship among proteins in cells,tissues,body fluids in a high flux, quickly identify,quantitative analytic way. The research that proteomics apply to early spontaneous abortion discovers that the pathogenesis relates to the superficial invasion of the trophocyte, the disfunction of the maternal-fetal vascular formation,oxidative stress,the maternal-fetal immune disfunction,the coagulation disorders, obesity and so on,it is benefit for early diagnosing. The research that proteomics apply to unexplained recurrent spontaneous abortion discovers that lymphocyte immunotherapy can maintain pregnancy and improve the outcomes of the pregnancy through improving the immune status. Now a review on proteomics and its application in early pregnancy abortion will be presented.
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    Neural Injury Theory in the Pathogenesis of Pelvic Organ Prolapse
    DAI Yu-xin;ZHANG Guo-rui;ZHU Lan
    2016, 43 (6):  703-707. 
    Abstract ( 1171 )   PDF (823KB) ( 5864 )  
    Pelvic organ prolapse (POP) is one of the most common gynecological disease of middle and aged women. Although the fundamental etiology of POP is not well explained yet, it is believed to be the consequences of the defect, damage and dysfunction in the supporting structures of pelvic. With the new concepts and technology research on POP, the neural injury theory has become one of the hottest topics in women urology research field. There is strong evidence from electrophysiological and pathophysiological study that nerve injury and its related neuropeptides deficiency may cause denervation of pelvic supportive muscles, which can play an essential role in POP development. This review will introduce the recent prevailing research work on pelvic floor nerve injury and pelvic floor denervation.
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    Progress of VEGF, JAK2/STAT3 Signaling Pathway in Gynecological Disease
    YIN Zhen-hui;YANG Hua
    2016, 43 (6):  708-712. 
    Abstract ( 1537 )   PDF (944KB) ( 5976 )  
    Signal transducer and activator of transcription 3 (STAT3) play an important role in many tissues as one of the members of the family of STATs. STAT3 is the main regulator in the process of cell growth. Janus kinase 2 (JAK2) is intracellular protein tyrosine kinase, which are involved in the signal transduction of hematopoietic and immune systems and play an important role in the signal transduction of a variety of cytokines. Vascular endothelial growth factor (VEGF) is a glycoprotein, a specific mitogen of endothelial cells, specifical to vascular endothelial cells, which can increase angiogenesis formation and vascular permeability. As an important substrate of JAK2, STAT3 plays a key role in the signal transduction of cytokines. The regulation of JAK2/STAT3 signaling pathway plays an important role in the maintenance of normal immunity. VEGF and JAK2/STAT3 signaling pathway regulate the target gene expression, promote the formation of neovascularization, directly involve in the disease occurrence and development process in gynecological tumor, endometriosis and other diseases. This paper briefly reviews the research progress of VEGF and JAK2/STAT3 signaling pathway in gynecological diseases.
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