Abstract: Pregnancy is similar to semi allograft transplantatioｎ，ｔhe imbalance of the maternal-fetal interface coordination is closely related to early pregnancy abortioｎ，ｓuch aｓ：early spontaneous abortion, recurrent spontaneous abortion, but the pathogenesises are unclear. Proteomics is a scientific discipline which can analysis the composition,function and the relationship among proteiｎｓ ｉｎ ｃｅｌｌｓ，ｔｉｓｓｕｅｓ，body fluids in a high flux, quickly identiｆｙ，quantitative analytic way. The research that proteomics apply to early spontaneous abortion discovers that the pathogenesis relates to the superficial invasion of the trophocyte, the disfunction of the maternal-fetal vascular formatiｏｎ，ｏxidative stresｓ，ｔｈe maternal-fetal immune disfunctioｎ，ｔｈe coagulation disorders, obesity and so ｏｎ，it is benefit for early diagnosing. The research that proteomics apply to unexplained recurrent spontaneous abortion discovers that lymphocyte immunotherapy can maintain pregnancy and improve the outcomes of the pregnancy through improving the immune status. Now a review on proteomics and its application in early pregnancy abortion will be presented.