Abstract: Large cell neuroendocrine carcinoma ( LCNEC ) of the uterine cervix is a rare but highly aggressive malignancy that tends to spread and recur early even in its early stage. The prognosis is very poor despite multimodal treatments. Neuroendocrine carcinomas sometimes are infected with high-risk human papillomavirus, but they are the subtype of cervical cancer that does not appear to be associated with human papillomavirus ( HPV ) exposure. The overwhelming majority of available data related to its treatment derive from retrospective analyses or small case series. Large-cell neuroendocrine carcinoma seem to behave similar to their more common counterpart, small-cell carcinoma, while large-cell carcinomas are extremely more rare and have a exceedingly different histologic appearance. Because of their peculiar clinical and biological features and the lack of literature data, there is an urgent need for a consensus on the best treatment approach for LCNEC and for the identification of new therapeutic options. The objective of this paper is to review the limited information available about the LCNEC and the diagnosis and treatmen.

Key words: Uterine cervical neoplasms, Carcinoma, neuroendocrine, Diagnosis, Treatment, Prognosis