Abstract:  Endometriosis (EMs) is a frequent occurrence of women with reproductive age, which mainly causes pain and infertility. As tumor growth and recurrence of ectopic EMs around the lesion vascularization degree of endothelial cell proliferation, metastasis and recurrence of EMs lesions of important factors, so the inhibition of vascular endothelial growth factor has become the new target of EMs treatment. Recent studies on the role of VEGF-A in EMs, such as VEGF, as a diagnostic marker of EMs, VEGF-A gene polymorphism, VEGF-A receptor inhibitor for the treatment of EMs and microRNA (miRNA) expression of VEGF in regulating, have made certain progress, help to further reveal the onset of EMs, recurrent focal shift and focal mechanisms, as well as more accurately assess the EMs of progression and recurrence. Recent advances in the research of VEGF-A in EMs are reviewed.

Key words: Endometriosis, Vascular endothelial growth factor A, Polymorphism, single nucleotide, Angiogenesis inhibitors, MicroRNAs