Abstract: Objective：To investigate the expression of peripheral blood inflammatory index in adenomyosis/ovarian heterotopic cysts systematicly and their correlation with clinical features, providing evidences for anti-inflammatory treatment of adenomyosis/ovarian heterotopic cysts. Methods：58 patients with uterine adenomyosis, 37 patients with ovarian heterotopic cysts, 47 age-matched women without diagnosed endometriosis (control group) were enrolled in our study. Blood inflammatory cytokines and tumor-associated antigens were analyzed by real-time polymerase chain reaction and immunofluore scence technique respectively. Results：The serum expression of Neu, Neu%, NLR, IL-6, IL-8, CA199 and CA125 in adenomyosis group was significantly higher than that in the control group (P＜0.05). The serum expression of HGB in adenomyosis group was significantly lower than that in the control group (Z=688.50, P=0.00). The serum expression of Neu, Neu%, NLR, IL-6, IL-8, TNF-α, CA199 and CA125 in ovary heterotopic cyst group was significantly higher than that in the control group (P＜0.05). WBC and CA125 were obviously higher in adenomyosis moderate dysmenorrhea group than in the mild dysmenorrhea group (P＜0.05). WBC, Neu, Neu%, NLR, IL-6 and IL-8 were significantly expressed in the severe dysmenorrhea group of adenomyosis compared with moderate dysmenorrhea group (P＜0.05). WBC, Neu, Neu%, NLR, IL-6, IL-8 and CA125 were significantly expressed in the severe dysmenorrhea group of adenomyosis compared with mild dysmenorrhea group (P＜0.05). The serum expression of HGB in  the severe and mild dysmenorrhea group of adenomyosis was significantly lower than that in the mild dysmenorrhea group (P＜0.05). WBC, Neu, Neu%, NLR, IL-6, IL-8, CA125 were clearly increased in adenomyosis hypermenorrhea group compared with normal menstruation group (P＜0.05). IL-6 and IL-8 were significantly expressed in the severe dysmenorrhea group of ovary heterotopic cyst compared with mild and moderate ovary heterotopic cyst group (P＜0.05). There was no significant correlation between tumor-associated antigenswere and peripheral blood inflammatory cytokines in adenomyosis/ovarian heterotopic cysts patients. Conclusions：Adenomyosis/ovarian heterotopic cysts was a state of systemic inflammatory stress and these indicators were associated with clinical features closely. The results are beneficial to provid a basis for anti-inflammatory treatment of adenomyosis/ovarian heterotopic cysts.

Key words: Endometriosis, Inflammation, Cytokines, Dysmenorrhea, Menorrhagia