Biological Effects of Sulforaphane and It′s Role in Female Reproductive System

Abstract

Abstract: Sulforaphane (1-isothiocyanate-4-methanesulfonylbutane, SFN), also known as raphanin, is a bioactive substance extracted from broccoli plants, and is one of the strong antioxidant found so far. Once oxidative stress stimulus occurs, sulforaphane can induce the expression of various antioxidants and detoxifying enzymes by activating the Nrf2/ARE pathway to exert an antioxidant effect. The sulforaphane can also directly react with other cellular targets to exert biological effects such as inducing apoptosis and regulating inflammatory mediators. Sulforaphane has been used as an antioxidant in various disease research, such as digestive disease, respiratory diseases, cardiovascular diseases and tumors. However, there are few studies on its function in the female reproductive system. This article reviews the basic structure, biological effects and research progress of sulforaphane in female reproductive system.

Key words: Sulforafan, Butanes, Urogenital system, Oxidative stress, Nrf2/ARE pathway

WU Hao, LU Xiao-sheng, LYU Jie-qiang. Biological Effects of Sulforaphane and It′s Role in Female Reproductive System[J]. Journal of International Obstetrics and Gynecology, 2019, 46(2): 216-219.

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