Abstract: Obesity may increase the incidence of gynecological malignant tumors and affect the prognosis by various mechanisms, such as chronic inflammation, dysregulation of sex hormones or abnormal secretion of adipokines, among which Leptin is one of the important adipokines and plays an important role in the occurrence and development of various gynecological malignant tumors. In different types of gynecological malignant tumors, leptin levels are different so it can be used as an independent risk factor for endometrial cancer. Leptin can activates a variety of signal transduction pathways by acting on Leptin receptors thus increasing tumor cell proliferation, migration, enhancing tumor cell invasiveness, promoting tumor angiogenesis and inhibiting tumor cell apoptosis. Understanding the relationship between Leptin and gynecological malignant tumors is helpful to better understand the pathogenesis of gynecological malignant tumors and has important clinical significance for preventing tumorigenesis, early diagnosis and prognosis of patients with advanced disease. In-depth research in this field will provide a new idea for the diagnosis and treatment of gynecological malignant tumors.

Key words: 【Keywords】Obesity, Leptin, Leptin Receptor, Gynecological Malignant Tumors