Abstract: Objective: To investigate the expressions of death receptor 5 (DR5) and apoptosis promoting protein (FADD) in uterine leiomyoma and their clinical significances. Methods: 72 patients who underwent hysteromyomectomy in our hospital from March 2017 to May 2018 were selected as the study subjects. The uterine leiomyoma tissue resected surgically was used as the myoma tissue group and the adjacent tissue 5 cm away from the edge of the tumor was used as the adjacent tissue group. Real-time fluorescence quantitative PCR (qRT-PCR) was used to detect the expressions of DR5 and FADD, the expressions of DR5 and FADD were detected by immunohistochemistry, TUNEL method was used to count apoptosis, and the correlations between DR5, FADD and apoptosis and the correlation between them was analyzed. Results: The positive expression rates of DR5 mRNA and protein in the myoma tissue group were higher than those in the adjacent tissue group (P＜0.05), and the positive expression rates of FADD mRNA and protein were lower than those in the adjacent tissue group (P＜0.05). AI in the myoma tissue group was lower than that in the adjacent tissue group, PI was higher than that in the adjacent tissue group (P＜0.05). In uterine leiomyoma, the expression of DR5 was negatively correlated with AI (P＜0.05), and positively correlated with PI (P＜0.05), the expression of FADD was positively correlated with AI (P＜0.05), and negatively correlated with PI (P＜0.05). DR5 was negatively correlated with FADD (P＜0.05). Conclusions: In uterine leiomyoma, DR5 is highly expressed, FADD expression is low, and they are negatively correlated. Both of them are significantly correlated with AI and PI, which may participate in the occurrence and development of uterine leiomyoma.

Key words: Leiomyoma, Receptors, tumor necrosis factor, Apoptosis, Apoptosis regulatory proteins, Uterine myomectomy