Abstract: Objective: To study the correlation between protein Z (PZ), protein Z-dependent protease inhibitor (ZPI) and other related blood coagulation indicators (PC, PS) in hypertensive disorders of pregnancy (HDP). Methods: 60 cases with HDP were selected from The Third Affiliated Hospital of Zhengzhou University from June 2017 to December 2018 as HDP group (60 cases) and research objects. It was divided into gestation hypertension group (25 cases) and pre-eclampsia group (PE group, 35 cases). 50 cases pregnancy women were selected as normal pregnancy group and 30 cases not pregnant women were selected as normal non-pregnant group, detect and compare the levels of PZ, ZPI in serum and PS, PC in plasma of each groups of women and investigate the correlation with HDP, evaluate the diagnostic value by ROC curve, analysis its research value for the disease. Results: ①The serum PZ and ZPI levels in the HDP group were lower than those in the normal pregnancy group, while the serum PZ and ZPI levels in the normal pregnancy group were higher than those in the normal non-pregnant group (P＜0.05). The serum PZ and ZPI levels were negatively correlated with the severity of HDP (P＜0.05), the correlation coefficients were -0.687 and -0.444 respectively. The areas under the corresponding ROC curves were 0.901 (95%CI: 0.853-0.948), 0.759 (95%CI: 0.676-0.841), the cut-off value were 31.52 ng/mL and 14.54 ng/mL respectively. ②The plasma PS and PC levels in the HDP group were lower than the other two groups (P＜0.05), there was no significant difference between normal pregnancy group and normal non-pregnancy group (P＞0.05). The plasma PC levels were negatively correlated with HDP (P＜0.05), the correlation coefficients were -0.340. The area under the ROC curve was 0.677 (95%CI: 0.586-0.769), the cut-off value was 108.08%. The plasma PS level has no correlation with HDP (P＞0.05). ③In the two subgroups of HDP group, the PZ and ZPI levels in the PE group were lower than those in the gestation hypertension group, there was no significant difference in the levels of PS and PC between the two groups (P＞0.05). Conclusions: By detecting the levels of PZ, ZPI, PS, PC in the blood of patients with HDP, the abnormalities of coagulation index can be found early, so that early intervention can be performed and minimize complications of HDP.

Key words: Hypertension, pregnancy-induced, Pregnancy complications, cardiovascular;, Protein Z;, Protein Z dependent protease inhibitor, Protein S;, Protein C;, Protease inhibitors