Abstract: Lung cancer in pregnancy is very rare, and the clinical manifestations are not typical, often found to be advanced, more poor prognosis. In the anti-tumor treatment, chemotherapy is the preferred treatment for most patients. The clinical data of one case of pregnancy complicated with lung cancer admitted to the First Affiliated Hospital of Zhengzhou University were analyzed retrospectively. The clinical characteristics of pregnancy complicated with lung cancer were analyzed based on previous literature and 71 cases. A total of 72 pregnant women with lung cancer were included in this study. Among the 72 cases, the median age of diagnosis was 34 years old; 64 cases of lung cancer were diagnosed during pregnancy, the median week was 31 weeks (6-38 weeks), 60 cases (93.75%) were diagnosed in the second and third trimester of pregnancy; 19 cases (26.39%) had a definite smoking history; 59 cases (81.94%) were non-small cell lung cancer, 13 cases (18.06%) were small cell lung cancer; 65 cases (90.28%) were clinical stage III or above; Among 60 cases with first diagnosis symptoms, there were 43 cases (71.67%) of cough, 32 cases (53.33%) of dyspnea, 12 cases (20.00%) of chest pain, 10 cases (16.67%) of hemoptysis, 13 cases (21.67%) of body weight reduction; the median gestational week of delivery was 33 weeks (26-42 weeks); 35 cases were treated in pregnancy, including 3 cases of early treatment, 23 cases of chemotherapy, 7 cases of targeted therapy, 5 cases of radiation therapy, 1 case of surgery. Among the 61 cases followed up, the 12-month survival rate was 26.23% after diagnosis of lung cancer. For this disease, we should pay attention to pre pregnancy screening and adverse reactions during pregnancy, early diagnosis, and improve the prognosis.

Key words: Lung neoplasms；, Pregnancy complications；, Therapy；, Prognosis；, Case reports