Abstract: Lymphoepithelioma-like carcinoma is defined as a poorly differentiated carcinoma with prominent lymphoplasmacytic infiltrate, which is commonly reported in the nasopharynx and remains a rare condition in gynecology. Lymphoepithelioma-like carcinoma of the vagina is a subtype of squamous cell carcinoma. Primary vaginal adenocarcinoma combined with lymphoepithelioma-like carcinoma has not been reported at home or abroad. We present a case of a young patient with primary vagina cancer and the tumor was a mixed poorly undifferentiated vaginal carcinoma consisting of adenocarcinoma and lymphoepithelioma-like carcinoma. Atypical glands and large infiltration of lymphocytes and plasma cells were seen under the microscope and immunohistochemistry showed CK(AE1/AE3)(+). This rare tumor of the vagina is difficult to diagnose both preoperatively and perioperatively. However, the poorly undifferentiated vaginal carcinoma with massive involvement of lymphoplasmacytic infiltrate indicates that the prognosis is relatively good. In order to improve the understanding of this disease, this study retrospectively analyzed the clinical data of the patient, reviewed relevant literature, and summarized the clinical features, pathological morphology and immunophenotype of this disease.

Key words: Vaginal neoplasms；, Adenocarcinoma；, Immunohistochemistry；, Lymphoepithelioma-like carcinoma