Abstract: Pre-eclampsia is one of the categories of hypertensive disorder complicating pregnancy, but its etiology and pathogenesis have not been clearly studied. Pre-eclampsia is a multi-factor, multi-mechanism and multi-pathway disease. At present, the main pathogenesis theories include insufficient recasting of uterine spiral arterioles, immune imbalance, oxidative stress, genetic factors and so on. Abnormal biological function of trophoblasts (proliferation, migration, invasion and apoptosis) may play a major role in the occurrence and development of pre-eclampsia, which will seriously affect maternal and infant health. Studies have shown that lncRNA was previously regarded as "transcriptional noise" with no biological function. However, with the rapid development of high-throughput sequencing technology and genome sequencing technology in recent years, it has been found that lncRNA can regulate the expression of various functions in the body. For example, lncRNA is abnormally expressed in the placenta of pre-eclampsia, which regulates the proliferation, migration, invasion and apoptosis of trophoblast cells through different target genes and signal pathways, thus leading to pre-eclampsia. Therefore, exploring the lncRNA associated with pre-eclampsia may provide a new way to understand the pathogenesis of pre-eclampsia and to identify new therapeutic targets. This review focuses on the regulation of trophoblast biology by abnormal expression of lncRNA in pre-eclampsia.

Key words: RNA, long noncoding, Pre-eclampsia, Trophoblast cell, Cell proliferation, Cell movement;, Neoplasm invasiveness;, Apoptosis