Abstract:

Endometriosis (EMs) often occurs in women of reproductive age. The main manifestations are pain, infertility and so on. Recent studies have found that a combination of the impact of local immune and inflammatory response on pregnancy, the impact of progesterone resistance in the endometrium, inadequate uterine contractility and thicken of the uterine junctional zone on implantation period can lead to third trimester adverse pregnancy outcomes. Studies have showed that compared to pregnant women with no-EMs, pregnant women with EMs have a significantly higher risk of placenta previa, it may be linked to inadequate uterine contractility. Furthermore, pregnant women with EMs are at higher risk of cesarean delivery, it may be associated with age, pelvic adhesion and increasing rate of late pregnancy complication. Whether the EMs increase the risk of placental abruption, preeclampsia, preterm birth, fetal growth restriction and postpartum hemorrhage in pregnant women is quite controversial. At the same time, during pregnancy we should be vigilant about the occurrence of the endometriosis-related acute complications, such as spontaneous hemoperitoneum in pregnancy. There is no evidence which shows the preventive surgery can reduce the risk of the adverse pregnancy outcomes, but it is essential to add some extra monitoring management of pregnant women with endometriosis who conceived by assisted reproductive technology.

Key words: Endometriosis, Placenta previa, Abruptio placentae, Pre-eclampsia, Premature birth, Fetal growth retardation, Cesarean section, Postpartum hemorrhage, Pregnancy outcomes, Reproductive technology, assisted