Advances in the Mechanism of Vaginal Microbiota in Cervical Cancer

doi:10.12280/gjfckx.20200753

Abstract

Abstract:

Cervical cancer is the most common malignant tumor in gynecology. The report "global cancer statistics 2018" shows that cervical cancer ranks fourth in morbidity and mortality in female tumors worldwide. The research on cervical cancer has always been the focus of gynecological scholars. In recent years, with the development of microbiome, the composition and changes of vaginal microbiota and the invasion of human papillomavirus (HPV), persistent infection and cervical cancer are gradually increasing. Lactobacillus dominates the normal cervicovaginal flora. It can maintain the balance of vaginal microecology, inhibit the growth of pathogenic microorganisms, and enhance the local anti-infection and anti-tumor ability of the vagina. It is expected to become a new strategy for the treatment of cervical cancer in the future. Current studies have shown that abnormal changes of vaginal microflora are associated with the occurrence and development of cervical cancer, and some vaginal bacteria play a role directly or indirectly through different mechanisms. This paper reviews the anti-cancer mechanism of vaginal microflora and its potential application in cervical cancer.

Key words: Uterine cervical neoplasms, Carcinoma, Vagina, Microbiota, Vaginosis, bacterial, Therapy

SU Ya-ting, NIU Wen-juan, DUAN Wen-jie, WEI Fang. Advances in the Mechanism of Vaginal Microbiota in Cervical Cancer[J]. Journal of International Obstetrics and Gynecology, 2021, 48(2): 126-130.

References 30

[1]	Kyrgiou M, Mitra A, Moscicki AB. Does the vaginal microbiota play a role in the development of cervical cancer?[J]. Transl Res, 2017,179:168-182. doi: 10.1016/j.trsl.2016.07.004. doi: 10.1016/j.trsl.2016.07.004 pmid: 27477083
[2]	Ravel J, Gajer P, Abdo Z, et al. Vaginal microbiome of reproductive-age women[J]. Proc Natl Acad Sci U S A, 2011,108 Suppl 1(Suppl 1): 4680-4687. doi: 10.1073/pnas.1002611107.
[3]	Yang X, Da M, Zhang W, et al. Role of Lactobacillus in cervical cancer[J]. Cancer Manag Res, 2018,10:1219-1229. doi: 10.2147/CMAR.S165228. doi: 10.2147/CMAR.S165228 pmid: 29844701
[4]	Nasioudis D, Forney LJ, Schneider GM, et al. The composition of the vaginal microbiome in first trimester pregnant women influences the level of autophagy and stress in vaginal epithelial cells[J]. J Reprod Immunol, 2017,123:35-39. doi: 10.1016/j.jri.2017.08.009. doi: 10.1016/j.jri.2017.08.009 pmid: 28915448
[5]	Lewis F, Bernstein KT, Aral SO. Vaginal Microbiome and Its Relationship to Behavior, Sexual Health, and Sexually Transmitted Diseases[J]. Obstet Gynecol, 2017,129(4):643-654. doi: 10.1097/AOG.0000000000001932. doi: 10.1097/AOG.0000000000001932 pmid: 28277350
[6]	Amabebe E, Anumba D. Psychosocial Stress, Cortisol Levels, Maintenance of Vaginal Health[J]. Front Endocrinol (Lausanne), 2018,9:568. doi: 10.3389/fendo.2018.00568.
[7]	Hearps AC, Tyssen D, Srbinovski D, et al. Vaginal lactic acid elicits an anti-inflammatory response from human cervicovaginal epithelial cells and inhibits production of pro-inflammatory mediators associated with HIV acquisition[J]. Mucosal Immunol, 2017,10(6):1480-1490. doi: 10.1038/mi.2017.27. pmid: 28401934
[8]	周绮萍, 高蕾. 阴道微生物群组与宫颈癌发生发展相关性的研究进展[J]. 临床肿瘤学杂志, 2020,25(5):472-477.
[9]	Wiik J, Sengpiel V, Kyrgiou M, et al. Cervical microbiota in women with cervical intra-epithelial neoplasia, prior to and after local excisional treatment, a Norwegian cohort study[J]. BMC Womens Health, 2019,19(1):30. doi: 10.1186/s12905-019-0727-0. doi: 10.1186/s12905-019-0727-0 pmid: 30728029
[10]	Lin M, Ye M, Zhou J, et al. Recent Advances on the Molecular Mechanism of Cervical Carcinogenesis Based on Systems Biology Technologies[J]. Comput Struct Biotechnol J, 2019,17:241-250. doi: 10.1016/j.csbj.2019.02.001. doi: 10.1016/j.csbj.2019.02.001 pmid: 30847042
[11]	朴金兰, 张睿怡. 阴道炎与HPV感染及宫颈上皮内瘤样变的关系及其机制[J]. 国际生殖健康/计划生育杂志, 2015,34(6):488-490.
[12]	Ghosh I, Muwonge R, Mittal S, et al. Association between high risk human papillomavirus infection and co-infection with Candida spp. and Trichomonas vaginalis in women with cervical premalignant and malignant lesions[J]. J Clin Virol, 2017,87:43-48. doi: 10.1016/j.jcv.2016.12.007. doi: 10.1016/j.jcv.2016.12.007 pmid: 27992790
[13]	Zhang D, Li T, Chen L, et al. Epidemiological investigation of the relationship between common lower genital tract infections and high-risk human papillomavirus infections among women in Beijing, China[J]. PLoS One, 2017,12(5):e0178033. doi: 10.1371/journal.pone.0178033. doi: 10.1371/journal.pone.0178033 pmid: 28531212
[14]	Mao C, Hughes JP, Kiviat N, et al. Clinical findings among young women with genital human papillomavirus infection[J]. Am J Obstet Gynecol, 2003,188(3):677-684. doi: 10.1067/mob.2003.164. doi: 10.1067/mob.2003.164 pmid: 12634640
[15]	李姝庆, 张阳阳, 伊艳茹, 等. 阴道微生态菌群与宫颈疾病相关性的研究进展[J]. 国际妇产科学杂志, 2020,47(2):223-226. doi: 10.3969/j.issn.1674-1870.2020.02.027.
[16]	阎冰冰. 阴道内环境与宫颈高危人乳头瘤病毒感染的关系[J]. 中国医药指南, 2018,16(9):99-100.
[17]	Zitvogel L, Daillère R, Roberti MP, et al. Anticancer effects of the microbiome and its products[J]. Nat Rev Microbiol, 2017,15(8):465-478. doi: 10.1038/nrmicro.2017.44. doi: 10.1038/nrmicro.2017.44 pmid: 28529325
[18]	郭馥艳, 闵琴琴, 钟阳青, 等. 乳酸杆菌药物治疗女性宫颈HPV感染的临床效果及对微生态环境的调节作用[J]. 中国现代药物应用, 2019,13(13):118-120. doi: 10.14164/j.cnki.cn11-5581/r.2019.13.067.
[19]	Riaz Rajoka MS, Zhao H, Lu Y, et al. Anticancer potential against cervix cancer (HeLa) cell line of probiotic Lactobacillus casei and Lactobacillus paracasei strains isolated from human breast milk[J]. Food Funct, 2018,9(5):2705-2715. doi: 10.1039/c8fo00547h. pmid: 29762617
[20]	Palma E, Recine N, Domenici L, et al. Long-term Lactobacillus rhamnosus BMX 54 application to restore a balanced vaginal ecosystem: a promising solution against HPV-infection[J]. BMC Infect Dis, 2018,18(1):13. doi: 10.1186/s12879-017-2938-z. pmid: 29304768
[21]	Negi D, Singh A, Joshi N, et al. Cisplatin and Probiotic Biomass Loaded Pessaries for the Management of Cervical Cancer[J]. Anticancer Agents Med Chem, 2020,20(5):589-598. doi: 10.2174/1871520619666191211110640. doi: 10.2174/1871520619666191211110640 pmid: 31823703
[22]	Wang KD, Xu DJ, Wang BY, et al. Inhibitory Effect of Vaginal Lactobacillus Supernatants on Cervical Cancer Cells[J]. Probiotics Antimicrob Proteins, 2018,10(2):236-242. doi: 10.1007/s12602-017-9339-x. doi: 10.1007/s12602-017-9339-x pmid: 29071554
[23]	Kim SN, Lee WM, Park KS, et al. The effect of Lactobacillus casei extract on cervical cancer cell lines[J]. Contemp Oncol (Pozn), 2015,19(4):306-312. doi: 10.5114/wo.2014.45292.
[24]	Li X, Wang H, Du X, et al. Lactobacilli inhibit cervical cancer cell migration in vitro and reduce tumor burden in vivo through upregulation of E-cadherin[J]. Oncol Rep, 2017,38(3):1561-1568. doi: 10.3892/or.2017.5791. doi: 10.3892/or.2017.5791 pmid: 28713905
[25]	Piqué N, Berlanga M, Miñana-Galbis D. Health Benefits of Heat-Killed (Tyndallized) Probiotics: An Overview[J]. Int J Mol Sci, 2019,20(10):2534. doi: 10.3390/ijms20102534.
[26]	Dasari S, Kathera C, Janardhan A, et al. Surfacing role of probiotics in cancer prophylaxis and therapy: A systematic review[J]. Clin Nutr, 2017,36(6):1465-1472. doi: 10.1016/j.clnu.2016.11.017. doi: 10.1016/j.clnu.2016.11.017 pmid: 27923508
[27]	Pio R, Ajona D, Ortiz-Espinosa S, et al. Complementing the Cancer-Immunity Cycle[J]. Front Immunol, 2019,10:774. doi: 10.3389/fimmu.2019.00774. doi: 10.3389/fimmu.2019.00774 pmid: 31031765
[28]	Bermúdez-Humarán LG, Kharrat P, Chatel JM, et al. Lactococci and lactobacilli as mucosal delivery vectors for therapeutic proteins and DNA vaccines[J]. Microb Cell Fact, 2011,10(Suppl 1):S4. doi: 10.1186/1475-2859-10-S1-S4.
[29]	逯彩虹. 乳酸杆菌在宫颈癌发病中作用及其增强树突状细胞疫苗抗肿瘤机制的研究[D]. 石家庄:河北医科大学, 2010.
[30]	Da Silva DM, Skeate JG, Chavez-Juan E, et al. Therapeutic efficacy of a human papillomavirus type 16 E7 bacterial exotoxin fusion protein adjuvanted with CpG or GPI-0100 in a preclinical mouse model for HPV-associated disease[J]. Vaccine, 2019,37(22):2915-2924. doi: 10.1016/j.vaccine.2019.04.043. doi: 10.1016/j.vaccine.2019.04.043 pmid: 31010714