Progress of Circulating Tumor Cell in the Diagnosis and Treatment of Epithelial Ovarian Cancer

doi:10.12280/gjfckx.20200979

Abstract

Abstract:

Ovarian cancer develops insidiously without particular early-stage symptoms. About 70% of the patients are found to have entered advanced stage, and have lost the best treatment opportunity. Circulating tumor cell(CTC) that shed from the primary tumor and enter the blood circulation are considered as tumor markers with great diagnostic and prognostic potential. Current studies have found that CTC detection is instructive for the early diagnosis, treatment efficacy monitoring and prognosis assessment of epithelial ovarian cancer, and may be a better monitoring method than CA-125. In recent years, more and more scholars have conducted in-depth studies on the detection methods and clinical applications of CTC in epithelial ovarian cancer. This paper reviews several typical methods for the capture and identification of CTC in epithelial ovarian cancer, the clinical significance of CTC in the diagnosis and treatment of epithelial ovarian cancer and the prospect of their clinical application and transformation.

Key words: Ovarian neoplasms, Neoplastic cells,circulating, Biomarkers,tumor, CA-125 antigen, Diagnosis, Therapy, Prognosis

QIN Zhao-juan, DU Yi, ZHENG Ai. Progress of Circulating Tumor Cell in the Diagnosis and Treatment of Epithelial Ovarian Cancer[J]. Journal of International Obstetrics and Gynecology, 2021, 48(4): 448-452.

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