Application of Organoids Technology in Drug Sensitivity Test of Ovarian Cancer

doi:10.12280/gjfckx.20210949

Abstract

Abstract:

Ovarian cancer has the highest fatality rate among gynecologic malignant tumors. Because the majority of ovarian cancer patients lack of specific symptoms and reliable biomarkers in the early stage, about 70% of patients are diagnosed at an advanced stage. The already existing preclinical models of ovarian cancer include cancer cell lines, animal models, patient-derived xenograft, patient-derived organoid, etc. The traditional preclinical models have their limitations. Therefore, in recent years, organoids are very popular as they can maintain the heterogeneities of the original tumors and simulate tumor microenvironment. At present, organoids are mainly used in cancer mechanism research, prognosis prediction, drug screening and so on. But so far, the technology of organoid has not been fully mature. In order to overcome the origin of organoid, 3D organoid culture system and microfluidics have come into being. The article will introduce the origin of organoid, the advantages and limitations of organoid in ovarian cancer research, and the application of organoid in the ovarian cancer drug sensitivity test.

Key words: Organoids, Drug screening assays,antitumor, Ovarian neoplasms, Carcinoma, Individualized treatment

WANG Ya-ni, JIANG Qi, ZHANG Yu-chen, ZHU Hai-yan. Application of Organoids Technology in Drug Sensitivity Test of Ovarian Cancer[J]. Journal of International Obstetrics and Gynecology, 2022, 49(2): 181-185.

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