Abstract:

Pre-eclampsia (PE) is a common clinical idiopathic pregnancy disease. Its condition changes dynamically, and its clinical manifestations are diversified. The etiology and mechanism have not been fully clarified so far. The main research results show that it is closely related to genetic factors, immune factors, nutritional factors and environmental factors. Recent studies have shown that the mammalian target of rapamycin (mTOR) signal pathway is involved in the regulation of placental trophoblast and vascular endothelial cell activity by regulating cell proliferation, invasion, migration and apoptosis, and insulin signal initiates downstream molecules to regulate cell metabolism by activating mTOR signal pathway, which leads to maternal vascular endothelial injury, damaged uterine spiral arteriole remodeling and abnormal inflammatory immune response, and so on, and participates in the occurrence of PE. The purpose of this review is to explore the correlation between mTOR signaling pathway and the pathogenesis of PE, and to provide theoretical basis for pathophysiological research and disease treatment of PE.

Key words: Pre-eclampsia, TOR serine-threonine kinases, Signal transduction, Trophoblasts, Endothelial cells, Insulin resistance