The Relationship between Inflammatory Cytokines and Embryo Arrest

doi:10.12280/gjfckx.20230007

Abstract

Abstract:

Embryo arrest is a common early pathological pregnancy in which is caused by defects of fertilized eggs or adverse pregnancy factors of the mother, resulting in the embryo to stop developing during pregnancy. The incidence of embryo arrest has increased year by year, becoming the most common complication of pregnancy. It may eventually lead to spontaneous abortion and missed abortion. Many factors are related to the occurrence of embryo arrest and about half of them are related to immune factors. Cytokines are a class of biologically active molecules that modulate immune response, among which inflammatory cytokines are related to inflammation. Uterine decidua and trophoblast cells can secrete a variety of inflammatory cytokines. Recent studies have shown that in the process of embryonic development, different cytokines cooperate, depend on and antagonize each other to form a cytokine network and participate in the maternal fetal interface immune response. But the exact mechanism of inducing embryo arrest is still unclear. This review focused on the relationship between inflammatory cytokines and embryo arrest and the related mechanism, in order to laying a theoretical foundation for the prevention of embryonic abortion and the development of targeted therapeutic agents.

Key words: Inflammation, Cytokines, Abortion, Immunoregulation, Signal transduction

LIU Bing-bing, XU Yan-ning, CHEN Ling. The Relationship between Inflammatory Cytokines and Embryo Arrest[J]. Journal of International Obstetrics and Gynecology, 2023, 50(4): 409-415.

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