Research Advances of Exosomes in Angiogenesis of Ovarian Cancer

doi:10.12280/gjfckx.20240329

Abstract

Abstract:

In the treatment of ovarian cancer, tumor cells often become resistant to chemotherapy drugs, leading to weakened or ineffective treatment outcomes. Therefore, anti-angiogenesis therapy serves as an important adjunctive treatment, can effectively slow disease progression by synergizing with other treatment modalities through various mechanisms. Exosomes, extracellular vesicles secreted by living cells, carry a variety of genetic materials and play crucial roles in cell communication within the tumor microenvironment. Studies have shown that exosomes derived from tumor cells and other cell sources can influence angiogenesis and other tumor-related processes by releasing non-coding RNAs, proteins, and other genetic materials. Utilizing exosomes to target specific proteins or as exogenous carriers for encapsulate therapeutic agents has become an important strategy for anti-angiogenesis therapy in ovarian cancer. This review summarized the regulatory mechanism of exosomes on angiogenesis in ovarian cancer and it also explores the potential of exosomes as anti-angiogenic agents, providing a theoretical basis for new treatment methods.

Key words: Exosomes, Ovarian neoplasms, Neovascularization, Therapy, Tumor microenvironment

ZHANG Jing-yi, LIU Dong-zhe, CHEN Xiu-hui. Research Advances of Exosomes in Angiogenesis of Ovarian Cancer[J]. Journal of International Obstetrics and Gynecology, 2024, 51(4): 370-374.

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