The Role and Treatment of Mitochondria in Endometrial Carcinoma

doi:10.12280/gjfckx.20240245

Abstract

Abstract:

Mitochondria are dynamic, semi-autonomous organelles widely found in mammalian cells and play an important role in maintaining normal endometrial cell homeostasis. Endometrial carcinoma is a common malignant tumor in women, and its age of onset is showing a trend towards younger age, so improving the ability to treat endometrial carcinoma is important to improve its prognosis. Recent studies have shown that abnormal mitochondrial biosynthesis process, dysregulation of mitochondrial dynamics, and mitochondrial dysfunction are closely related to the occurrence and development of endometrial carcinoma. Mitochondria also show great potential in endometrial carcinoma treatment, such as induction of apoptosis and targeting of mitochondria-associated endometrial carcinoma stem cells.Deeply understanding of the role of mitochondria in the pathogenesis of endometrial carcinoma will provide new perspectives for endometrial carcinoma treatment.

Key words: Mitochondria, Endometrial neoplasms, DNA, mitochondrial, Mitochondrial dynamics, Regulated cell death, Mitochondrial biosynthesis

ZHANG Yi-tian, LI Xiao-li. The Role and Treatment of Mitochondria in Endometrial Carcinoma[J]. Journal of International Obstetrics and Gynecology, 2024, 51(4): 375-379.

References 30

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