Research Progress on the Application of Corticosteroids in Late Preterm Twin Pregnancies

doi:10.12280/gjfckx.20260100

Abstract

Abstract:

The preterm birth rate in twin pregnancies is 47.6%-69.0%, with the late preterm birth rate ranging from 33.0% to 59.8%, which is significantly higher than in singleton pregnancies. The use of antenatal corticosteroids (ACS) before 34 weeks of gestation can effectively reduce complications such as neonatal mortality, but its application in late preterm birth is controversial, especially in twin pregnancies. Most studies support that ACS can reduce respiratory complications such as respiratory distress syndrome in late preterm neonates from twin pregnancies. However, some studies find no clear association between them, and the effect is inferior to that in singleton pregnancies. The long-term impact of ACS on the neurological development of late preterm infants from twin pregnancies is not yet clear. Some evidence suggests a possible increased risk of cognitive developmental delays, attention deficits, and hyperactivity disorders. Animal experiments have also verified the potential neuroinjury mechanisms of ACS. Concurrently, ACS may increase the risk of hypoglycemia in late preterm infants from twin pregnancies, and hypoglycemia also has a potential association with long-term neurodevelopmental abnormalities. Currently, there is a lack of consensus in both domestic and international guidelines regarding the routine use of ACS in late preterm twin pregnancies, with most recommending individualized decision-making.

Key words: Pregnancy, twin, Infant, Premature, Late preterm birth, Adrenal cortex hormones, Respiratory system, Hypoglycemia, Nervous system

LOU Ying-ya, GAO Juan-mei, ZHAI Hong-bo. Research Progress on the Application of Corticosteroids in Late Preterm Twin Pregnancies[J]. Journal of International Obstetrics and Gynecology, 2026, 53(3): 249-254.

Figures/Tables 2

References 46

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